Zhang YZ, Yao JN, Zhang LF, Wang CF, Zhang XX, Gao B. Effect of NLRC5 on activation and reversion of hepatic stellate cells by regulating the nuclear factor-κB signaling pathway. World J Gastroenterol 2019; 25(24): 3044-3055 [PMID: 31293340 DOI: 10.3748/wjg.v25.i24.3044]
Corresponding Author of This Article
Yan-Zhen Zhang, MD, Doctor, Department of Second Gastroenterology, the First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou 450052, Henan Province, China. zhangyz8848@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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Zhang YZ, Yao JN, Zhang LF, Wang CF, Zhang XX, Gao B. Effect of NLRC5 on activation and reversion of hepatic stellate cells by regulating the nuclear factor-κB signaling pathway. World J Gastroenterol 2019; 25(24): 3044-3055 [PMID: 31293340 DOI: 10.3748/wjg.v25.i24.3044]
Yan-Zhen Zhang, Jian-Ning Yao, Lian-Feng Zhang, Chun-Feng Wang, Xue-Xiu Zhang, Bing Gao, Department of Second Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Author contributions: Zhang YZ, Yao JN, and Zhang LF designed the research; Zhang YZ, Yao JN, and Wang CF performed the research; Zhang LF and Wang CF contributed new reagents and analytic tools; Zhang XX and Gao B analyzed the data; Zhang YZ, Yao JN, Zhang LF, Wang CF, Zhang XX, and Gao B wrote the paper.
Institutional review board statement: The study was approved by the ethics committee of the First Affiliated Hospital of Zhengzhou University.
Institutional animal care and use committee statement: The study was approved by the institutional animal care and use committee of the First Affiliated Hospital of Zhengzhou University.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Corresponding author: Yan-Zhen Zhang, MD, Doctor, Department of Second Gastroenterology, the First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou 450052, Henan Province, China. zhangyz8848@163.com
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Received: March 20, 2019 Peer-review started: March 20, 2019 First decision: April 4, 2019 Revised: April 27, 2019 Accepted: June 1, 2019 Article in press: June 1, 2019 Published online: June 28, 2019 Processing time: 101 Days and 5 Hours
Core Tip
Core tip: Liver fibrosis is a pathological tissue repair process characterized by excessive deposition of extracellular matrix in the liver, accompanied by inflammation, and eventually progresses to cirrhosis. Several recent reports have shown that effective treatment can reverse liver fibrosis, which is associated with inactivation of hepatic stellate cells (HSCs) and multiple signaling pathways. NOD-like receptor (NLR) family, caspase activation and recruitment domain (CARD) domain containing 5/NOD27/CLR16.1 (NLRC5) is the largest member of the NLR family and is highly expressed in immune tissues or organs such as the spleen, lung, thymus, and liver, mediating inflammation inhibition and antiviral response. This study aimed to investigate the role of NLRC5 in activating and devitalization of HSCs and its mechanism. The results demonstrate that NLRC5 may be involved in the development and reversal of liver fibrosis by negative regulation of nuclear factor-κB.
