Gong SN, Zhu JP, Ma YJ, Zhao DQ. Proteomics of the mediodorsal thalamic nucleus of rats with stress-induced gastric ulcer. World J Gastroenterol 2019; 25(23): 2911-2923 [PMID: 31249449 DOI: 10.3748/wjg.v25.i23.2911]
Corresponding Author of This Article
Dong-Qin Zhao, PhD, Associate Professor, College of Life Sciences, Shandong Normal University, No. 88, East Wenhua Road, Lixia District, Jinan 250014, Shandong Province, China. zhaodq@sdnu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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Gong SN, Zhu JP, Ma YJ, Zhao DQ. Proteomics of the mediodorsal thalamic nucleus of rats with stress-induced gastric ulcer. World J Gastroenterol 2019; 25(23): 2911-2923 [PMID: 31249449 DOI: 10.3748/wjg.v25.i23.2911]
Sheng-Nan Gong, Jian-Ping Zhu, Ying-Jie Ma, Dong-Qin Zhao, College of Life Sciences, Shandong Normal University, Jinan 250014, Shandong Province, China
Author contributions: Zhao DQ and Zhu JP designed the experiments; Ma YJ and Gong SN performed the experiments; Zhao DQ performed mass spectrometry analysis and wrote the manuscript; Gong SN analyzed the protemoics data; Zhu JP analyzed the GM and EI data; Ma YJ analyzed the WB data; all the authors approved the final version of the manuscript for publication.
Supported byNational Natural Science Foundation of China, No. 31501861; and Natural Science Foundation of Shandong Province, China, No. ZR2015CM013.
Institutional animal care and use committee statement: All procedures were approved by the Institutional Animal Care and Use Committee of Shandong Normal University (Jinan, People’s Republic of China; No. AEECSDNU2018003).
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Corresponding author: Dong-Qin Zhao, PhD, Associate Professor, College of Life Sciences, Shandong Normal University, No. 88, East Wenhua Road, Lixia District, Jinan 250014, Shandong Province, China. zhaodq@sdnu.edu.cn
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Received: January 27, 2019 Peer-review started: January 27, 2019 First decision: March 20, 2019 Revised: May 8, 2019 Accepted: May 18, 2019 Article in press: May 18, 2019 Published online: June 21, 2019 Processing time: 145 Days and 20.7 Hours
Core Tip
Core tip: Quantitative proteomic analysis was used to screen for differentially expressed proteins in the mediodorsal thalamic nucleus of rats subjected to restraint water-immersion stress. A total of 65 dysregulated proteins were identified, which are mainly involved in the neurological disease signalling pathways. Meanwhile, the 31 upregulated proteins are primarily related to cell division, whereas the 34 downregulated proteins are related to neuron morphogenesis and neurotransmitter regulation. Furthermore, glycogen synthase kinase-3 beta might be related to the central mechanism through which restraint water-immersion stress gives rise to stress-induced gastric ulcer (SGU). Proteomic analysis elucidated the nervous system molecular targets of SGU.
