Jing HR, Luo FW, Liu XM, Tian XF, Zhou Y. Fish oil alleviates liver injury induced by intestinal ischemia/reperfusion via AMPK/SIRT-1/autophagy pathway. World J Gastroenterol 2018; 24(7): 833-843 [PMID: 29467553 DOI: 10.3748/wjg.v24.i7.833]
Corresponding Author of This Article
Yun Zhou, MD, Doctor, Department of Clinical Nutrition, Second Affiliated Hospital of Dalian Medical University, No. 467, Zhongshan Road, Shahekou District, Dalian 116023, Liaoning Province, China. zydy2ynutrition@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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Jing HR, Luo FW, Liu XM, Tian XF, Zhou Y. Fish oil alleviates liver injury induced by intestinal ischemia/reperfusion via AMPK/SIRT-1/autophagy pathway. World J Gastroenterol 2018; 24(7): 833-843 [PMID: 29467553 DOI: 10.3748/wjg.v24.i7.833]
Hui-Rong Jing, Fu-Wen Luo, Xing-Ming Liu, Xiao-Feng Tian, Department of General Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China
Yun Zhou, Department of Clinical Nutrition, Second Affiliated Hospital of Dalian Medical University, Dalian 116023, Liaoning Province, China
Author contributions: Jing HR and Luo FW performed the majority of experiments and almost equally contributed to the present study; Luo FW and Liu XM provided vital reagents and analytical tools and were also involved in editing the manuscript; Jing HR coordinated and provided the collection of all the human material in addition to providing financial support for this work; Tian XF and Zhou Y designed the study and wrote the manuscript.
Supported by the National Natural Science Foundation of China, No. 81600446; Natural Science Foundation of Liaoning Province, China, No. 201102048; and Natural Science Foundation of Dalian Medical Association, No. WSJ/KJC-01-JL-01.
Institutional review board statement: The study was reviewed and approved by the review board of Dalian Medical University, Liaoning Province, China.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Dalian Medical University (Permit number: SCXK 2008-0002).
Conflict-of-interest statement: There is no conflict of interest in this study.
Data sharing statement: No additional data are available.
Correspondence to: Yun Zhou, MD, Doctor, Department of Clinical Nutrition, Second Affiliated Hospital of Dalian Medical University, No. 467, Zhongshan Road, Shahekou District, Dalian 116023, Liaoning Province, China. zydy2ynutrition@126.com
Received: October 28, 2017 Peer-review started: October 30, 2017 First decision: November 15, 2017 Revised: December 25, 2017 Accepted: January 15, 2018 Article in press: January 15, 2018 Published online: February 21, 2018 Processing time: 102 Days and 21.2 Hours
Core Tip
Core tip: Intestinal ischemia/reperfusion (I/R) injury is a remarkable problem in many clinical conditions. Increased evidence indicates AMPK/SIRT-1 pathway linked autophagy exhibits a protective effect in liver diseases. Fish oil (FO) emulsion improves outcomes in patients with parenteral nutrition associated liver injury. We aimed to evaluate whether FO can protect liver injury induced by intestinal I/R via the AMPK/SIRT-1/autophagy pathway. Our results indicate that FO may protect the liver against intestinal I/R induced injury through the AMPK/SIRT-1/autophagy pathway. To our knowledge, we maybe for the first time present that FO attenuated intestinal I/R induced liver injury by inducing autophagy both in vivo and in vitro through the AMPK/SIRT-1 signaling pathway.
