Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2018; 24(45): 5095-5108
Published online Dec 7, 2018. doi: 10.3748/wjg.v24.i45.5095
Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model
Karen Jackson, Noa Dressler, Rotem S Ben-Shushan, Ari Meerson, Tyler W LeBaron, Snait Tamir
Karen Jackson, Noa Dressler, Rotem S Ben-Shushan, Ari Meerson, Snait Tamir, Laboratory of Human Health and Nutrition Sciences, MIGAL-Galilee Research Institute, Kyriat Shmona 11016, Israel
Karen Jackson, Noa Dressler, Snait Tamir, Tel Hai College, Upper Galilee 12110, Israel
Tyler W LeBaron, Center of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, Bratislava 84005, Slovakia
Tyler W LeBaron, Molecular Hydrogen Institute, UT 48101, United States
Author contributions: Jackson K designed and coordinated the research analyzed the data and wrote the paper; Dressler N performed the majority of experiments and analyzed the data; Ben-Shushan RS performed the perfusion, and in vitro experiments; Meerson A designed and analyzed the PCR data, LeBaron TW analyzed the data and wrote the paper; Tamir S analyzed the data and contributed to the writing of the final draft.
Supported by Tel Hai College Research funding Grant, No. 25-2-14-114.
Correspondence author to: Karen Jackson, PhD, Senior Lecturer, Senior Researcher, Laboratory of Human Health and Nutrition Sciences, MIGAL-Galilee Research Institute, POB 831, Kyriat Shmona 11016, Israel. karen@migal.org.il
Telephone: +972-4-6953511 Fax: +972-4-6944980
Received: September 30, 2018
Peer-review started: September 30, 2018
First decision: October 23, 2018
Revised: October 31, 2018
Accepted: November 9, 2018
Article in press: November 9, 2018
Published online: December 7, 2018
Processing time: 67 Days and 19.7 Hours
Core Tip

Core tip: In this work, we compared the effects of two functional waters: Electrolyzed alkaline water and Hydrogen-rich water in a high-fat-diet-induced nonalcoholic fatty liver disease (NAFLD) mouse model. Hydrogen-rich water (HRW) has potential for NAFLD treatment by attenuating hepatic lipid accumulation, inflammation, and CD36 expression. However, neither electrolyzed-alkaline water (EAW) nor HRW with a low H2 concentration had protective effects on NAFLD. Additionally, we demonstrated that H2 pretreatment has a protective effect by modifying gene expression. The results demonstrate that H2 has a surprisingly positive impact in preventing NAFLD in mice and is also the key agent responsible in EAW for these benefits.