©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2018; 24(44): 4979-4988
Published online Nov 28, 2018. doi: 10.3748/wjg.v24.i44.4979
Published online Nov 28, 2018. doi: 10.3748/wjg.v24.i44.4979
Glutathione depleting drugs, antioxidants and intestinal calcium absorption
Luciana Moine, María Rivoira, Gabriela Díaz de Barboza, Adriana Pérez, Nori Tolosa de Talamoni, Laboratorio “Dr. Fernando Cañas”, Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba 5000, Argentina
Author contributions: Moine L, Rivoira M, Díaz de Barboza G, Pérez A and Tolosa de Talamoni NT participated in information collection, analysis, information organization, writing, figure design, and final editing.
Conflict-of-interest statement: No conflicts of interest, financial or otherwise, are declared by the authors.
Corresponding author to: Nori Tolosa de Talamoni, PhD, Professor, Laboratorio “Dr. Fernando Cañas”, Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Pabellón Argentina, 2do. Piso, Ciudad Universitaria, Córdoba 5000, Argentina. ntolosa@biomed.fcm.unc.edu.ar
Telephone: +54-351-4333024
Received: August 28, 2018
Peer-review started: August 28, 2018
First decision: October 9, 2018
Revised: October 24, 2018
Accepted: November 2, 2018
Article in press: November 2, 2018
Published online: November 28, 2018
Processing time: 91 Days and 12.2 Hours
Peer-review started: August 28, 2018
First decision: October 9, 2018
Revised: October 24, 2018
Accepted: November 2, 2018
Article in press: November 2, 2018
Published online: November 28, 2018
Processing time: 91 Days and 12.2 Hours
Core Tip
Core tip: The normal content of glutathione (GSH) in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs.