Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2018; 24(34): 3898-3907
Published online Sep 14, 2018. doi: 10.3748/wjg.v24.i34.3898
Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer
Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Chao-Hui Zheng, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ping Li, Chang-Ming Huang
Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Chao-Hui Zheng, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ping Li, Chang-Ming Huang, Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China
Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Chao-Hui Zheng, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ping Li, Chang-Ming Huang, Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350108, Fujian Province, China
Jian-Xian Lin, Xin-Sheng Xie, Xiong-Feng Weng, Chao-Hui Zheng, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Ping Li, Chang-Ming Huang, Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou 350108, Fujian Province, China
Author contributions: Lin JX, Xie XS and Weng XF contributed equally to this article and should be considered co-first authors; Li P and Huang CM conceived and designed the study and are the co-corresponding authors; Lin JX, Xie XS and Weng XF performed the experiments; Zheng CH, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M and Tu RH analyzed and interpreted the data; Lin JX, Xie XS and Weng XF drafted the manuscript. All authors approved the final version of the article to be published.
Supported by the Science Foundation of the Fujian Province, China, No. 2018J01307; Startup Fund for Scientific Research, Fujian Medical University, No. 2016QH024; Scientific and Technological Innovation Joint Capital Projects of Fujian Province, No. 2016Y9031; Minimally Invasive Medical Center of Fujian Province, No. 2011708#; and the Young and Middle-aged Talent Training Project of the Fujian Provincial Health and Family Planning Commission, No. 2014-ZQNJC-13.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Fujian Medical University Union Hospital.
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chang-Ming Huang, MD, Doctor, Professor, Department of Gastric Surgery, Fujian Medical University Union Hospital, No.29 Xinquan Road, Fuzhou 350001, Fujian Province, China. hcmlr2002@163.com
Telephone: +86-591-83363366 Fax: +86-591-83363366
Received: May 19, 2018
Peer-review started: May 22, 2018
First decision: May 30, 2018
Revised: June 11, 2018
Accepted: June 25, 2018
Article in press: June 25, 2018
Published online: September 14, 2018
Processing time: 117 Days and 22.3 Hours
Core Tip

Core tip: The expression of CDK5RAP3 and DDRGK1 was down-regulated in gastric cancer tissues. Low expression CDK5RAP3 or DDRGK1 is a poor prognostic factor for gastric cancer patients. The co-expression of CDK5RAP3 and DDRGK1 is an independent prognostic factor for the overall survival of patients with gastric cancer. Moreover, we also found that co-expression of CDK5RAP3 and DDRGK1 can provide a more accurate model for the long-term prognosis of gastric cancer.