©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2018; 24(34): 3821-3833
Published online Sep 14, 2018. doi: 10.3748/wjg.v24.i34.3821
Published online Sep 14, 2018. doi: 10.3748/wjg.v24.i34.3821
Implication of neurohormonal-coupled mechanisms of gastric emptying and pancreatic secretory function in diabetic gastroparesis
Bashair M Mussa, Sanjay Sood, Department of Basic Medical Science, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates
Anthony JM Verberne, Department of Medicine, Austin Health, University of Melbourne, Melbourne 3084, Australia
Author contributions: Mussa BM developed, designed and wrote the review; Sood S designed the figures and revised the manuscript; Verberne AJ edited and revised the manuscript; all authors approved the final version.
Conflict-of-interest statement: The authors have no personal, financial or non-financial conflicts of interest.
Correspondence to: Bashair M Mussa, PhD, Assistant Professor, Department of Basic Medical Science, College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates. bmussa@sharjah.ac.ae
Telephone: +971-6-5057220 Fax: +971-6-558579
Received: May 21, 2018
Peer-review started: May 21, 2018
First decision: June 13, 2018
Revised: June 22, 2018
Accepted: June 27, 2018
Article in press: June 27, 2018
Published online: September 14, 2018
Processing time: 116 Days and 4 Hours
Peer-review started: May 21, 2018
First decision: June 13, 2018
Revised: June 22, 2018
Accepted: June 27, 2018
Article in press: June 27, 2018
Published online: September 14, 2018
Processing time: 116 Days and 4 Hours
Core Tip
Core tip: Prevalence of diabetic gastroparesis (DGP) is increasing in a dramatic fashion, however there are still gaps in our understanding of the pathophysiology of DGP. It well documented that gastric emptying and subsequent pancreatic secretion are interrelated and regulated by several neurohormonal mechanisms. Dysfunction of these mechanisms affects gastric emptying, pancreatic secretion and postprandial glycemia. Therefore, the present article reviews the neurohormonal-coupled mechanisms that control gastric emptying and pancreatic secretion and their plausible involvement in DGP. This will help in identification of novel therapeutic targets to treat DGP with minimal adverse effects on postprandial glycemia.