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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2018; 24(3): 338-350
Published online Jan 21, 2018. doi: 10.3748/wjg.v24.i3.338
Published online Jan 21, 2018. doi: 10.3748/wjg.v24.i3.338
Effect of Lactobacillus rhamnosus GG supernatant on serotonin transporter expression in rats with post-infectious irritable bowel syndrome
Ya-Nan Cao, Yuan-Yuan Liu, Kui Jiang, Bang-Mao Wang, Jia Gao, Ze-Lan Wang, Yu-Ming Wang, Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin 300052, China
Li-Juan Feng, Department of Functional Division, Xingtai People’s Hospital, Xingtai 054031, Hebei Province, China
Mao-Jun Zhang, Yi-Xin Gu, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Author contributions: Cao YN and Feng LJ contributed to essential research and statistical analysis; Wang YM, Jiang K, and Wang BM designed the study; Zhang MJ, Gu YX and Liu YY were mainly responsible for cultivation of bacteria, Gao J, Liu YY and Wang ZL contributed to raising animals; Cao YN and Feng LJ edited the article; Wang YM supported the financial arrangement.
Supported by the National Natural Science Foundation of China, No. 81570489.
Institutional review board statement: This study was approved by the Tianjin Medical University General Hospital.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Animal Ethics and Welfare Committee of Tianjin Medical University.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: Readers can get the data of this paper by contacting us via E-mail: ywang12@tmu.edu.cn.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yu-Ming Wang, MD, PhD, Attending Physician, Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, China. ywang12@tmu.edu.cn
Telephone: +86-22-60362608 Fax: +86-22-60363768
Received: November 9, 2017
Peer-review started: November 9, 2017
First decision: November 30, 2017
Revised: December 6, 2017
Accepted: December 12, 2017
Article in press: December 12, 2017
Published online: January 21, 2018
Processing time: 71 Days and 5.8 Hours
Peer-review started: November 9, 2017
First decision: November 30, 2017
Revised: December 6, 2017
Accepted: December 12, 2017
Article in press: December 12, 2017
Published online: January 21, 2018
Processing time: 71 Days and 5.8 Hours
Core Tip
Core tip: There are few reports on the effect of the supernatant of Lactobacillus rhamnosus GG (LGG) on serotonin transporter (SERT) expression in rats with post-infectious irritable bowel syndrome (PI-IBS). An experimental rat model of PI-IBS was developed by Campylobacter jejuni infection. SERT levels in intestinal and brain tissues were detected to evaluate the effect of LGG-s.