Bravo D, Hoare A, Soto C, Valenzuela MA, Quest AF. Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects. World J Gastroenterol 2018; 24(28): 3071-3089 [PMID: 30065554 DOI: 10.3748/wjg.v24.i28.3071]
Corresponding Author of This Article
Andrew FG Quest, PhD, Professor, Advanced Center for Chronic Diseases, Center for Studies on Exercise, Metabolism and Cancer, Biomedical Science Institute, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Santiago 8380447, Chile. aquest@med.uchile.cl
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Review
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Bravo D, Hoare A, Soto C, Valenzuela MA, Quest AF. Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects. World J Gastroenterol 2018; 24(28): 3071-3089 [PMID: 30065554 DOI: 10.3748/wjg.v24.i28.3071]
World J Gastroenterol. Jul 28, 2018; 24(28): 3071-3089 Published online Jul 28, 2018. doi: 10.3748/wjg.v24.i28.3071
Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects
Denisse Bravo, Anilei Hoare, Cristopher Soto, Manuel A Valenzuela, Andrew FG Quest
Denisse Bravo, Anilei Hoare, Cristopher Soto, Oral Microbiology Laboratory, Pathology and Oral Medicine Department, Faculty of Dentistry, Universidad de Chile, Santiago 8380492, Chile
Manuel A Valenzuela, Advanced Center for Chronic Diseases, Institute for Health-Related Research and Innovation, Faculty of Health Sciences, Universidad Central de Chile, Santiago 8380447, Chile
Andrew FG Quest, Advanced Center for Chronic Diseases, Center for Studies on Exercise, Metabolism and Cancer, Biomedical Science Institute, Faculty of Medicine, Universidad de Chile, Santiago 8380447, Chile
Author contributions: Bravo D, Hoare A, Soto C, Valenzuela MA and Quest AF contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version; Bravo D, Hoare A and Soto C were involved in the design of Table 1 and Figure 1.
Supported byComisión Nacional de Investigación Científica y Tecnológica-Fondos de Financiamiento de Centros de Investigación en Áreas Prioritarias, No. 15130011 (to Quest AF); Fondo Nacional de Desarrollo Científico y Tecnológico, No. 1170925 (to Quest AF) and No. 1171615 (to Valenzuela MA); Fondo para la Investigación en Odontología Universidad de Chile, No. 17/020 (to Bravo D).
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Correspondence to: Andrew FG Quest, PhD, Professor, Advanced Center for Chronic Diseases, Center for Studies on Exercise, Metabolism and Cancer, Biomedical Science Institute, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Santiago 8380447, Chile. aquest@med.uchile.cl
Telephone: +56-2-27382015 Fax: +56-2-27382015
Received: April 10, 2018 Peer-review started: April 10, 2018 First decision: April 26, 2018 Revised: May 17, 2018 Accepted: June 27, 2018 Article in press: June 27, 2018 Published online: July 28, 2018 Processing time: 108 Days and 19.4 Hours
Core Tip
Core tip: This review focuses on discussing how Helicobacter pylori (H. pylori) has co-evolved with humans, potential mechanisms that may explain both positive and negative correlations in population-based studies between H. pylori infection and the development of several diseases, as well as how inflammation and/or changes in the microbiome might be linked to the respective outcomes. Our analysis of the literature reveals that human infection by H. pylori has a longstanding history, whereby the consequences therefore are extremely complex and not always detrimental to the human host. Thus, future research should focus on determining how potentially beneficial consequences of this interaction could be promoted all the while preventing the disease-causing effects in humans.
