©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2018; 24(24): 2582-2595
Published online Jun 28, 2018. doi: 10.3748/wjg.v24.i24.2582
Published online Jun 28, 2018. doi: 10.3748/wjg.v24.i24.2582
Direct-acting antivirals and hepatocellular carcinoma in chronic hepatitis C: A few lights and many shadows
Maria Guarino, Anna Sessa, Valentina Cossiga, Federica Morando, Nicola Caporaso, Filomena Morisco, Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples 80131, Italy
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: None of the authors had personal or financial conflict of interest.
Correspondence to: Nicola Caporaso, MD, Full Professor, Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Via S. Pansini5, Naples 80131, Italy. nicola.caporaso@unina.it
Telephone: +39-08-17462761 Fax: +39-08-17464746
Received: April 19, 2018
Peer-review started: April 21, 2018
First decision: May 9, 2018
Revised: May 18, 2018
Accepted: June 9, 2018
Article in press: June 12, 2018
Published online: June 28, 2018
Processing time: 67 Days and 8.2 Hours
Peer-review started: April 21, 2018
First decision: May 9, 2018
Revised: May 18, 2018
Accepted: June 9, 2018
Article in press: June 12, 2018
Published online: June 28, 2018
Processing time: 67 Days and 8.2 Hours
Core Tip
Core tip: A significant debate about the impact of direct-acting antiviral agents (DAAs) on the development of hepatocellular carcinoma (HCC) is currently ongoing. After a full review of the published literature, the evidence does not suggest that there is a higher rate of de novo HCC occurrence or recurrence after DAA therapy in patients with previous hepatitis C virus infection.