©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2018; 24(23): 2508-2517
Published online Jun 21, 2018. doi: 10.3748/wjg.v24.i23.2508
Published online Jun 21, 2018. doi: 10.3748/wjg.v24.i23.2508
Clinical and prognostic significance of Raf kinase inhibitory protein expression in gastrointestinal stromal tumors
Yang Wang, Juan-Juan Chen, Xiao-Fei Wang, Qiang Wang, Department of Gastrointestinal Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Wang Y designed research; Wang Y performed research; Wang Y and Chen JJ contributed new reagents or analytic tools; Wang Y and Wang XF analyzed data; Wang Y wrote the paper; Wang Q edited the paper and provided primary revised opinion.
Institutional review board statement: The study was reviewed and approved by Sheng-Jing Hospital of China Medical University Institutional Review Board.
Informed consent statement: The patient involved in this study gave her written informed consent authorizing use and disclosure of her protected health information.
Conflict-of-interest statement: All the authors have no conflicts of interests to declare.
CONSORT 2010 statement: the guidelines of the CONSORT 2010 Statement have been adopted.
Correspondence to: Qiang Wang, PhD, Doctor, Professor, Department of Gastrointestinal Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China. wangq@sj-hospital.org
Telephone: +86-24-96615
Received: March 14, 2018
Peer-review started: March 14, 2018
First decision: March 30, 2018
Revised: April 5, 2018
Accepted: April 26, 2018
Article in press: April 26, 2018
Published online: June 21, 2018
Processing time: 93 Days and 0.5 Hours
Peer-review started: March 14, 2018
First decision: March 30, 2018
Revised: April 5, 2018
Accepted: April 26, 2018
Article in press: April 26, 2018
Published online: June 21, 2018
Processing time: 93 Days and 0.5 Hours
Core Tip
Core tip: In this study, the expression of Raf kinase inhibitory protein (RKIP) in gastrointestinal stromal tumors (GISTs) was examined by immunohistochemistry. We explored the relationship between RKIP protein expression and survival and prognosis in a large sample of GIST patients in China. RKIP protein expression was correlated with tumor growth, differentiation, malignancy, and the prognosis of the tumor. Our findings provide evidence for the diagnosis and prognosis assessment of GIST and offer new tumor treatment targets in GIST.