©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 28, 2018; 24(16): 1725-1733
Published online Apr 28, 2018. doi: 10.3748/wjg.v24.i16.1725
Published online Apr 28, 2018. doi: 10.3748/wjg.v24.i16.1725
Nucleotide-binding oligomerization domain 1 and Helicobacter pylori infection: A review
Kosuke Minaga, Tomohiro Watanabe, Ken Kamata, Masatoshi Kudo, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan
Naoki Asano, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi 980-8574, Japan
Author contributions: Minaga K and Watanabe T wrote the manuscript draft and prepared the figures; Kamata K, Asano N and Kudo M assisted in writing the manuscript and reviewed the final version.
Conflict-of-interest statement: None of the authors has any conflict of interests related to this manuscript.
Correspondence to: Tomohiro Watanabe, MD, PhD, Associate Professor, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan. tomohiro@med.kindai.ac.jp
Telephone: +81-72-366-0221 Fax: +81-72-367-2880
Received: March 6, 2018
Peer-review started: March 6, 2018
First decision: March 29, 2018
Revised: April 3, 2018
Accepted: April 9, 2018
Article in press: April 9, 2018
Published online: April 28, 2018
Processing time: 51 Days and 19.4 Hours
Peer-review started: March 6, 2018
First decision: March 29, 2018
Revised: April 3, 2018
Accepted: April 9, 2018
Article in press: April 9, 2018
Published online: April 28, 2018
Processing time: 51 Days and 19.4 Hours
Core Tip
Core tip: Nucleotide-binding oligomerization domain 1 (NOD1), an intracellular innate immune sensor, plays a role in mucosal host defense systems against Helicobacter pylori (H. pylori) infection. NOD1 activation is involved in the generation of T helper type 1 responses against H. pylori through activation of type I IFN signaling pathways. NOD1 activation prevents gastric carcinogenesis through negative regulation of caudal-related homeobox 2 expression.