©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2018; 24(14): 1507-1520
Published online Apr 14, 2018. doi: 10.3748/wjg.v24.i14.1507
Published online Apr 14, 2018. doi: 10.3748/wjg.v24.i14.1507
Hepatitis B virus pre-S/S variants in liver diseases
Bing-Fang Chen, School of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan
Author contributions: Chen BF wrote the paper.
Supported by the grant from the National Science Council (NSC 96-2320-B-030-004-MY3), Executive Yuan, Taiwan.
Conflict-of-interest statement: No potential conflicts of interest.
Correspondence to: Bing-Fang Chen, PhD, Professor, School of Medicine, Fu-Jen Catholic University, 510 Chung-Cheng Road, Hsin-Chuang Dist, New Taipei City 24205, Taiwan. nurs1018@mail.fju.edu.tw
Telephone: +886-2-29053428 Fax: +886-2-29052096
Received: March 8, 2018
Peer-review started: March 9, 2018
First decision: March 21, 2018
Revised: March 29, 2018
Accepted: March 31, 2018
Article in press: March 31, 2018
Published online: April 14, 2018
Processing time: 33 Days and 23.1 Hours
Peer-review started: March 9, 2018
First decision: March 21, 2018
Revised: March 29, 2018
Accepted: March 31, 2018
Article in press: March 31, 2018
Published online: April 14, 2018
Processing time: 33 Days and 23.1 Hours
Core Tip
Core tip: Naturally occurring hepatitis B virus (HBV) pre-S/S variants have been identified and associated with progressive liver diseases. In this review, the author discusses five pre-S/S variants: pre-S deletion, pre-S point mutation, pre-S1 splice variant, C-terminus S point mutation, and pre-S/S nonsense mutation. Their associations with HBV genotype and the possible pathogenesis of pre-S/S variants are also discussed. Different pre-S/S variants cause liver diseases through different mechanisms. Most cause the intracellular retention of HBV envelope proteins and induction of endoplasmic reticulum stress, resulting in liver diseases. The exact pathogenesis of pre-S/S variants requires further investigation.