Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2018; 24(13): 1398-1409
Published online Apr 7, 2018. doi: 10.3748/wjg.v24.i13.1398
Systems pharmacology approach reveals the antiinflammatory effects of Ampelopsis grossedentata on dextran sodium sulfate-induced colitis
You-Lan Chen, Ya-Li Zhang, Yan-Cheng Dai, Zhi-Peng Tang
You-Lan Chen, Ya-Li Zhang, Zhi-Peng Tang, Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
You-Lan Chen, Yan-Cheng Dai, Zhi-Peng Tang, Department of Gastroenterology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Author contributions: Chen YL performed the majority of experiments and drafted the paper; Zhang YL participated in the treatment of animals; Dai YC analyzed the data; Tang ZP designed and coordinated the research; all authors have approved the final version of the article to be published.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Shanghai University of Traditional Chinese Medicine (IACUC Protocol Approval Number: SZY201710004).
Conflict-of-interest statement: The authors declare that there are no conflicts of interest related to this study.
Data sharing statement: Supplementary data accompanying this paper are included in the Supplementary information file.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zhi-Peng Tang, MD, PhD, Professor, Director, Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. zhipengtang@sohu.com
Telephone: +86-21-64385700 Fax: +86-21-64385700
Received: January 27, 2018
Peer-review started: January 28, 2018
First decision: February 10, 2018
Revised: February 12, 2018
Accepted: March 3, 2018
Article in press: March 3, 2018
Published online: April 7, 2018
Processing time: 67 Days and 9.3 Hours
Core Tip

Core tip: Ulcerative colitis (UC), as one of the major forms of inflammatory bowel disease, could lead to various intestinal and extra-intestinal manifestations, which brings a huge challenge to the health care system. Given studies have confirmed that the flavonoid bioactive compounds contained in Ampelopsis grossedentata (AMP) possess strong antiinflammatory activity, we examined the potential therapeutic effects of AMP on UC based on systems pharmacology. Results showed that AMP could suppress the inflammation-related signaling pathways in dextran sulfate sodium-induced colitis, indicating protective effects on UC, which might provide an effective natural therapy for the treatment and prevention of UC.