Zhang WG, Linghu EQ, Li HK. Fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy: A retrospective study at a single center. World J Gastroenterol 2017; 23(9): 1637-1644 [PMID: 28321165 DOI: 10.3748/wjg.v23.i9.1637]
Corresponding Author of This Article
En-Qiang Linghu, MD, Department of Gastroenterology, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com
Research Domain of This Article
Surgery
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Mar 7, 2017; 23(9): 1637-1644 Published online Mar 7, 2017. doi: 10.3748/wjg.v23.i9.1637
Fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy: A retrospective study at a single center
Wen-Gang Zhang, En-Qiang Linghu, Hui-Kai Li
Wen-Gang Zhang, En-Qiang Linghu, Hui-Kai Li, Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Zhang WG analyzed the data and wrote the manuscript; Li HK acquired the data; Linghu EQ designed the research.
Institutional review board statement: The study was carried out under the ethics committee approval from the Chinese PLA General Hospital (Beijing China).
Informed consent statement: Informed consent was waived due to the retrospective nature of this study.
Conflict-of-interest statement: We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work.
Data sharing statement: No additional data was available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: En-Qiang Linghu, MD, Department of Gastroenterology, Chinese PLA General Hospital, No. 28, Fuxing Road, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com
Telephone: +86-135-01233558 Fax: +86-10-66937485
Received: November 25, 2016 Peer-review started: November 25, 2016 First decision: January 10, 2017 Revised: January 22, 2017 Accepted: February 7, 2017 Article in press: February 8, 2017 Published online: March 7, 2017 Processing time: 101 Days and 2.9 Hours
Core Tip
Core tip: Mucosal penetration is one of the most dangerous adverse events during peroral endoscopic myotomy (POEM). We first reported the feasibility of fibrin sealant for closure of mucosal penetration at the cardia in two cases in 2012. However, there remains a lack of evidence about the treatment response to fibrin sealant for mucosal penetration in a cohort of patients who experienced this complication. Thus, we retrospective identified and analyzed the cases for 21 patients who experienced a mucosal penetration and received fibrin sealant for penetration closure during POEM, providing further support for the efficacy and safety of fibrin sealant for penetration closure. Moreover, instructions regarding the usage of fibrin sealant for penetration closure were provided for endoscopists who might be worried about mucosal penetrations during POEM.
