Zhang ML, Jiang YF, Wang XR, Ding LL, Wang HJ, Meng QQ, Gao PJ. Different phenotypes of monocytes in patients with new-onset mild acute pancreatitis. World J Gastroenterol 2017; 23(8): 1477-1488 [PMID: 28293095 DOI: 10.3748/wjg.v23.i8.1477]
Corresponding Author of This Article
Pu-Jun Gao, MD, PhD, Department of Hepatology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, Jilin Province, China. pujun-gao@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
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Zhang ML, Jiang YF, Wang XR, Ding LL, Wang HJ, Meng QQ, Gao PJ. Different phenotypes of monocytes in patients with new-onset mild acute pancreatitis. World J Gastroenterol 2017; 23(8): 1477-1488 [PMID: 28293095 DOI: 10.3748/wjg.v23.i8.1477]
Man-Li Zhang, Qing-Qing Meng, Department of Hepatology and Gastroenterology, The Second Part of First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Man-Li Zhang, Yan-Fang Jiang, Xin-Rui Wang, Hong-Juan Wang, Department of Central Laboratory, The Second Part of First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Xin-Rui Wang, Hong-Juan Wang, Pu-Jun Gao, Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Yan-Fang Jiang, Key Laboratory of Zoonosis Research, Ministry of Education, Jilin University, Changchun 130021, Jilin Province, China
Li-Li Ding, Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Gao PJ designed the research; Zhang ML, Wang XR and Wang HJ performed the research; Zhang ML, Ding LL and Meng QQ analyzed the data; Zhang ML and Jiang YF wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Human Ethics Committee of the First Hospital of Jilin University.
Conflict-of-interest statement: The authors declare no financial or commercial conflicts of interest.
Data sharing statement: No additional data are available.
Correspondence to: Pu-Jun Gao, MD, PhD, Department of Hepatology, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, Jilin Province, China. pujun-gao@163.com
Telephone: +86-431-84808239 Fax: +86-431-84808391
Received: September 30, 2016 Peer-review started: October 8, 2016 First decision: December 19, 2016 Revised: January 13, 2017 Accepted: January 17, 2017 Article in press: January 17, 2017 Published online: February 28, 2017 Processing time: 149 Days and 8.4 Hours
Core Tip
Core tip: This is the first study on the numbers of different phenotypes of peripheral blood monocytes in patients with new-onset mild acute pancreatitis (MAP). Increased numbers of CD14+CD163- and CD14+CD163-MAC387+ M1 monocytes were positively correlated with the levels of plasma C-reactive protein (CRP), which suggest that pro-inflammatory monocytes may participate in the pathogenesis of MAP. The increased numbers of CD14+CD163+CD115+ M2 monocytes were positively correlated with the plasma CRP levels and the acute physiology and chronic health evaluation II scores, suggesting that the numbers of CD14+CD163+CD115+ monocytes may be a valuable biomarker for evaluating the severity of MAP. Our findings may provide new insights into the pathogenic process and immunoregulation of MAP.
