World J Gastroenterol. Feb 21, 2017; 23(7): 1289-1297 Published online Feb 21, 2017. doi: 10.3748/wjg.v23.i7.1289
Esophagogastric junction distensibility assessed using the functional lumen imaging probe
Joan W Chen, Joel H Rubenstein
Joan W Chen, Joel H Rubenstein, Department of Gastroenterology and Hepatology, University of Michigan Health Systems, Ann Arbor, MI 48109, United States
Author contributions: Chen JW and Rubenstein JH contributed to the study concept and design, acquisition of data, analysis and interpretation, critical revision, and final approval of the manuscript; Chen JW drafted of the manuscript.
Conflict-of-interest statement: Chen JW and Rubenstein JH have no commercial, personal, political, intellectual, or religious conflict of interest.
Data sharing statement: Technical appendix and dataset available from the corresponding author at chenjoan@med.umich.edu.
Correspondence to: Joan W Chen, MD, MS, Department of Gastroenterology and Hepatology, University of Michigan Health Systems, 3912 Taubman Center, 1500 E. Medical Center Dr., SPC 5362, Ann Arbor, MI 48109, United States. chenjoan@med.umich.edu
Telephone: +1-734-9366400 Fax: +1-734-9366400
Received: October 8, 2016 Peer-review started: October 9, 2016 First decision: November 9, 2016 Revised: December 8, 2016 Accepted: December 21, 2016 Article in press: December 21, 2016 Published online: February 21, 2017 Processing time: 135 Days and 17.7 Hours
Core Tip
Core tip: Functional lumen imaging probe (FLIP) uses impedance planimetry to calculate the distensibility of a hollow organ. In this systematic review, we aimed to assess FLIP reference values for gastroesophageal junction distensibility in healthy and diseased states. We found available normative data to vary widely. In achalasia, patients uniformly demonstrated low distensibility that improved after treatment, highlighting the role of FLIP in assessment of achalasia treatment efficacy. In gastroesophageal reflux disease, distensibility fell to the range of untreated achalasia following fundoplication, emphasizing the importance of pre-operative screening for esophageal body dysmotililty. Future studies using a standardized FLIP protocol and balloon size are needed.
