Deng CW, Wang L, Fei YY, Hu CJ, Yang YJ, Peng LY, Zeng XF, Zhang FC, Li YZ. Exploring pathogenesis of primary biliary cholangitis by proteomics: A pilot study. World J Gastroenterol 2017; 23(48): 8489-8499 [PMID: 29358857 DOI: 10.3748/wjg.v23.i48.8489]
Corresponding Author of This Article
Yong-Zhe Li, MD, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing 100730, China. yongzhelipumch@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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Deng CW, Wang L, Fei YY, Hu CJ, Yang YJ, Peng LY, Zeng XF, Zhang FC, Li YZ. Exploring pathogenesis of primary biliary cholangitis by proteomics: A pilot study. World J Gastroenterol 2017; 23(48): 8489-8499 [PMID: 29358857 DOI: 10.3748/wjg.v23.i48.8489]
World J Gastroenterol. Dec 28, 2017; 23(48): 8489-8499 Published online Dec 28, 2017. doi: 10.3748/wjg.v23.i48.8489
Exploring pathogenesis of primary biliary cholangitis by proteomics: A pilot study
Chui-Wen Deng, Li Wang, Yun-Yun Fei, Chao-Jun Hu, Yun-Jiao Yang, Lin-Yi Peng, Xiao-Feng Zeng, Feng-Chun Zhang, Yong-Zhe Li
Chui-Wen Deng, Li Wang, Yun-Yun Fei, Chao-Jun Hu, Yun-Jiao Yang, Lin-Yi Peng, Xiao-Feng Zeng, Feng-Chun Zhang, Yong-Zhe Li, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Chui-Wen Deng, Li Wang, Yun-Yun Fei, Chao-Jun Hu, Yun-Jiao Yang, Lin-Yi Peng, Xiao-Feng Zeng, Feng-Chun Zhang, Yong-Zhe Li, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China.
Author contributions: Deng CW, Wang L, Fei YY and Li YZ designed the study; Deng CW, Wang L and Fei YY performed the study; Hu CJ, Yang YJ and Peng LY collected the samples; Li YZ contributed new reagents and analytic tools; Deng CW analyzed the data and wrote the paper; Zeng XF and Zhang FC proofread the paper.
Supported by the National Natural Science Foundation of China, No. 81302591, No. 81373188, and No. 81671618; the Capital Health Research and Development of Special, No. 2014-1-4011; and the Research Special Fund for Public Welfare Industry of Health, No. 201202004.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of the Peking Union Medical College Hospital.
Conflict-of-interest statement: The authors declare that no competing interests exist
Data sharing statement: No additional data are available.
Correspondence to: Yong-Zhe Li, MD, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan, Dongcheng District, Beijing 100730, China. yongzhelipumch@126.com
Telephone: +86-10-69159966 Fax: +86-10-69159966
Received: October 30, 2017 Peer-review started: October 31, 2017 First decision: November 14, 2017 Revised: November 21, 2017 Accepted: November 28, 2017 Article in press: November 28, 2017 Published online: December 28, 2017 Processing time: 57 Days and 22.2 Hours
Core Tip
Core tip: The pathogenesis of primary biliary cholangitis (PBC) is still unclear. Related studies have focused on genes, immune cells, and pathology. However, little research has been conducted to establish pathogenesis-related autoantibodies. In this study, we unraveled the pathogenesis of PBC by detecting novel autoantibodies, using proteomics. Our results suggest that the dysfunction of three pathways in human intrahepatic biliary epithelial cells might be causative in the pathogenesis of antimitochondrial antibody (AMA)-negative PBC. More interestingly, we identified AMA-negative pathology as a potential misnomer, as we detected low levels of AMA in sera of AMA-negative patients. Comprehensive research is needed to confirm these observations.
