Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2017; 23(47): 8308-8320
Published online Dec 21, 2017. doi: 10.3748/wjg.v23.i47.8308
Effects of initiating time and dosage of Panax notoginseng on mucosal microvascular injury in experimental colitis
Shi-Ying Wang, Ping Tao, Hong-Yi Hu, Jian-Ye Yuan, Lei Zhao, Bo-Yun Sun, Wang-Jun Zhang, Jiang Lin
Shi-Ying Wang, Ping Tao, Hong-Yi Hu, Lei Zhao, Bo-Yun Sun, Wang-Jun Zhang, Jiang Lin, Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Shi-Ying Wang, Hong-Yi Hu, Jian-Ye Yuan, Institute of Digestive Diseases, China-Canada Center of Research for Digestive Diseases (ccCRDD), Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Author contributions: Wang SY performed the experiments, prepared the figures, and contributed to the manuscript writing; Tao P, Zhao L, Sun BY and Zhang WJ performed the experiments and analyzed the data; Tao P and Zhang WJ provided research materials; Yuan JY and Hu HY contributed to experimental design; Lin J contributed to experimental design, interpretation of data, and manuscript writing, and supervised the project; all authors approved the final version.
Supported by the National Natural Science Foundation of China, No. 81373616.
Institutional review board statement: The following study has been reviewed and approved by the Institutional Review Board of Longhua Hospital, Shanghai University of Traditional Chinese Medicine.
Institutional animal care and use committee statement: All procedures involving animals in the following manuscript were reviewed and approved by the Institutional Animal Care and Use Committee of Shanghai University of Traditional Chinese Medicine (No. SZY201612006).
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jiang Lin, PhD, MD, Chief Doctor, Professor, Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725, South Wanping Road, Shanghai 200032, China. linjiang@longhua.net
Telephone: +86-21-64385700 Fax: +86-21-64398310
Received: September 6, 2017
Peer-review started: September 7, 2017
First decision: October 10, 2017
Revised: November 3, 2017
Accepted: November 14, 2017
Article in press: November 14, 2017
Published online: December 21, 2017
Processing time: 105 Days and 0.5 Hours
Core Tip

Core tip:Panax notoginseng (PN) is a traditional Chinese medicine used to treat ulcerative colitis, but its mechanisms are unclear. In our study, we found that PN promoted repair of injuries of colonic mucosa and microvessels in rat colitis. PN decreased concentrations of vascular endothelial growth factor, interleukin (IL)-6 and tumor necrosis factor-α while it increased the concentrations of IL-4 and IL-10 in serum. It also decreased concentrations of myeloperoxidase and hypoxia-inducible factor-1α while it increased the concentration of superoxide dismutase in colon. So it is concluded that PN repairs mucosal and vascular injuries in rat colitis via attenuating inflammation and oxidative stress in the colonic mucosa.