Piatek-Guziewicz A, Ptak-Belowska A, Przybylska-Felus M, Pasko P, Zagrodzki P, Brzozowski T, Mach T, Zwolinska-Wcislo M. Intestinal parameters of oxidative imbalance in celiac adults with extraintestinal manifestations. World J Gastroenterol 2017; 23(44): 7849-7862 [PMID: 29209126 DOI: 10.3748/wjg.v23.i44.7849]
Corresponding Author of This Article
Tomasz Brzozowski, MD, PhD, Professor, Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, Cracow 31-531, Poland. mpbrzozo@cyf-kr.edu.pl
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
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Piatek-Guziewicz A, Ptak-Belowska A, Przybylska-Felus M, Pasko P, Zagrodzki P, Brzozowski T, Mach T, Zwolinska-Wcislo M. Intestinal parameters of oxidative imbalance in celiac adults with extraintestinal manifestations. World J Gastroenterol 2017; 23(44): 7849-7862 [PMID: 29209126 DOI: 10.3748/wjg.v23.i44.7849]
World J Gastroenterol. Nov 28, 2017; 23(44): 7849-7862 Published online Nov 28, 2017. doi: 10.3748/wjg.v23.i44.7849
Intestinal parameters of oxidative imbalance in celiac adults with extraintestinal manifestations
Malgorzata Zwolinska-Wcislo, Tomasz Mach, Tomasz Brzozowski, Pawel Zagrodzki, Pawel Pasko, Magdalena Przybylska-Felus, Agata Ptak-Belowska, Agnieszka Piatek-Guziewicz
Agnieszka Piatek-Guziewicz, Department of Gastroenterology and Hepatology, University Hospital, Cracow 31531, Poland
Agata Ptak-Belowska, Tomasz Brzozowski, Department of Physiology, Jagiellonian University Medical College, Cracow 31531, Poland
Magdalena Przybylska-Felus, Tomasz Mach, Malgorzata Zwolinska-Wcislo, Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Cracow 31531, Poland
Pawel Pasko, Pawel Zagrodzki, Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, Cracow 30688, Poland
Pawel Zagrodzki, Henryk Niewodniczanski Institute of Nuclear Physics, Cracow 31342, Poland
Author contributions: Piatek-Guziewicz A, Zwolinska-Wcislo M and Ptak-Belowska A designed the research; Piatek-Guziewicz A, Ptak-Belowska A, Przybylska-Felus M, Pasko P and Zagrodzki P performed the research; Ptak-Belowska A analyzed the data; Piatek-Guziewicz A and Zwolinska-Wcislo M wrote the paper; Mach T and Brzozowski T revised and edited the manuscript for final submission.
Supported byMinistry of Science and Higher Education, No. K/ZDS/003811.
Institutional review board statement: The study was reviewed and approved by the Local Ethics Committee at Jagiellonian University Medical College in Cracow, Poland (No. KBET/174/B/2013).
Informed consent statement: All study participants, or their legal guardians, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.
Correspondence to: Tomasz Brzozowski, MD, PhD, Professor, Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, Cracow 31-531, Poland. mpbrzozo@cyf-kr.edu.pl
Telephone: +48-12-4211006 Fax:+48-12-4222014
Received: October 11, 2017 Peer-review started: October 11, 2017 First decision: October 18, 2017 Revised: November 3, 2017 Accepted: November 14, 2017 Article in press: November 14, 2017 Published online: November 28, 2017 Processing time: 47 Days and 16.3 Hours
Core Tip
Core tip: Oxidative stress has been implicated in gliadin toxicity. Additional measures aimed at reducing oxidative imbalance may prove to be effective supplementary therapy. We demonstrated increased duodenal expression of hypoxia-inducible factor 1 (HIF-1α), heat-shock protein 70 (HSP-70), and superoxide dismutase in adult celiac patients with extraintestinal manifestations as a defensive reaction to oxidative stress. Hence, HSP-70 and HIF-1α might be potential novel biomarkers of celiac disease (CD). Increased HSP-70 expression, both in treated and untreated celiac patients, suggests that oxidative stress as well as histopathological alterations in duodenal mucosa persist despite gluten-free diet. Our data confirm the increased serum levels of uric acid in patients with CD compared with controls as a result of oxidative stress.
