Autoimmune hepatitis: Standard treatment and systematic review of alternative treatments

doi:10.3748/wjg.v23.i33.6030

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World Journal of Gastroenterology

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1007-9327

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Review

World J Gastroenterol. Sep 7, 2017; 23(33): 6030-6048
Published online Sep 7, 2017. doi: 10.3748/wjg.v23.i33.6030

Autoimmune hepatitis: Standard treatment and systematic review of alternative treatments

Benedetta Terziroli Beretta-Piccoli, Giorgina Mieli-Vergani, Diego Vergani

Benedetta Terziroli Beretta-Piccoli, Epatocentro Ticino, 6900 Lugano, Switzerland

Giorgina Mieli-Vergani, Paediatric Liver, GI and Nutrition Centre, MowatLabs, King’s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom

Diego Vergani, Institute of Liver Studies, MowatLabs, King’s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom

Author contributions: Terziroli Beretta-Piccoli B contributed to writing up the manuscript; Mieli-Vergani G and Vergani D contributed to critical revision and final approval of the report.

Conflict-of-interest statement: No potential conflicts of interest.

Correspondence to: Diego Vergani, Professor, Institute of Liver Studies, MowatLabs, King’s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom. diego.vergani@kcl.ac.uk

Telephone: +44-20-32994643 Fax: +44-20-32994224

Received: June 6, 2017
Peer-review started: June 7, 2017
First decision: June 22, 2017
Revised: July 18, 2017
Accepted: August 2, 2017
Article in press: August 2, 2017
Published online: September 7, 2017
Processing time: 93 Days and 15.5 Hours

Core Tip

Core tip: The first part of this review summarizes the standard therapeutic approach for autoimmune hepatitis (steroids and azathioprine) and the evidence on which it is based. The second part reviews systematically published data on first and second line alternative treatments. This information is summarized in two comprehensive tables, one for adult and one for paediatric patients.