©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2017; 23(26): 4675-4688
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4675
Published online Jul 14, 2017. doi: 10.3748/wjg.v23.i26.4675
Present and future of metastatic colorectal cancer treatment: A review of new candidate targets
Giulia Martini, Teresa Troiani, Claudia Cardone, Pietropaolo Vitiello, Vincenzo Sforza, Davide Ciardiello, Stefania Napolitano, Carminia Maria Della Corte, Floriana Morgillo, Fortunato Ciardiello, Erika Martinelli, Department of Internal and Experimental Medicine “F. Magrassi e A. Lanzara”, Institute of Medical Oncology, Università degli studi della Campania Luigi Vanvitelli, 80131 Naples, Italy
Antonio Raucci, Department of Internal and Experimental Medicine, Magrassi-Lanzara, Institute of Radiology, Università degli studi della Campania Luigi Vanvitelli, 80138 Naples, Italy
Antonio Cuomo, Gastroenterology Unit, Ospedale Umberto I, 84104 Nocera Inferiore, Italy
Francesco Selvaggi, Unit of Colorectal Surgery, Department of Medical, Surgical, Neurological, Metabolic and Ageing Sciences, Università degli studi della Campania Luigi Vanvitelli, 80138 Naples, Italy
Author contributions: Martini G performed the research and wrote the paper; Troiani T, Cardone C, Vitiello P, Sforza V, Ciardiello D, Napolitano S, Della Corte C, Morgillo F, Raucci A, Cuomo A, Selvaggi F, Ciardiello F and Martinelli E contributed to the critical revision of the manuscript for important intellectual content.
Conflict-of-interest statement: Authors have no conflict of interest to declare.
Correspondence to: Erika Martinelli, MD, PhD, Assistant Professor, Department of Internal and Experimental Medicine “F. Magrassi e A. Lanzara”, Institute of Medical Oncology, Università degli studi della Campania Luigi Vanvitelli, via Pansini 5, 80131 Naples, Italy. erika.martinelli@unina2.it
Telephone: +39-81-5666628 Fax: +39-81-5666732
Received: January 27, 2017
Peer-review started: February 6, 2017
First decision: March 16, 2017
Revised: April 21, 2017
Accepted: June 1, 2017
Article in press: June 1, 2017
Published online: July 14, 2017
Processing time: 165 Days and 7.8 Hours
Peer-review started: February 6, 2017
First decision: March 16, 2017
Revised: April 21, 2017
Accepted: June 1, 2017
Article in press: June 1, 2017
Published online: July 14, 2017
Processing time: 165 Days and 7.8 Hours
Core Tip
Core tip: Colorectal cancer is a heterogeneous disease characterized by several molecular alterations that affect genes implicated in cancer development. The discovery of novel biomarkers, together with a better understand of the complex biology of the disease, is essential to identify patients who will most likely benefit from personalized treatment.