©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 7, 2017; 23(25): 4500-4507
Published online Jul 7, 2017. doi: 10.3748/wjg.v23.i25.4500
Published online Jul 7, 2017. doi: 10.3748/wjg.v23.i25.4500
Localization and role of metabotropic glutamate receptors subtype 5 in the gastrointestinal tract
Andrea Ferrigno, Clarissa Berardo, Laura G Di Pasqua, Veronica Siciliano, Plinio Richelmi, Mariapia Vairetti, Department of Internal Medicine and Therapeutics (Cellular and Molecular Pharmacology and Toxicology), University of Pavia, 27100 Pavia, Italy
Author contributions: Ferrigno A contributed to data acquisition, data interpretation, composition of the draft and approval of the final version; Berardo C, Di Pasqua LG and Siciliano V contributed to data acquisition, critical revision and approval of the final version; Richelmi P contributed to data interpretation, critical revision and approval of the final version; Vairetti M contributed to conception of the study, design of the study, data interpretation, critical revision and approval of the final version.
Supported by Italian ministry of University, Research and Instruction .
Conflict-of-interest statement: Ferrigno A, Berardo C, Di Pasqua LG, Siciliano V, Richelmi P and Vairetti M declare no conflict of interest related to this publication.
Correspondence to: Andrea Ferrigno, PhD, Department of Internal Medicine and Therapeutics (Cellular and Molecular Pharmacology and Toxicology), University of Pavia, Via Ferrata 9A, 27100 Pavia, Italy. andrea.ferrigno@unipv.it
Telephone: +39-382-986451 Fax: +39-382-986347
Received: February 4, 2017
Peer-review started: February 5, 2017
First decision: April 26, 2017
Revised: May 3, 2017
Accepted: June 19, 2017
Article in press: June 19, 2017
Published online: July 7, 2017
Processing time: 160 Days and 11.4 Hours
Peer-review started: February 5, 2017
First decision: April 26, 2017
Revised: May 3, 2017
Accepted: June 19, 2017
Article in press: June 19, 2017
Published online: July 7, 2017
Processing time: 160 Days and 11.4 Hours
Core Tip
Core tip: Metabotropic glutamate 5 receptors (mGluR5s) belong to Group I mGlu receptors which are coupled to the inositol trisphosphate/diacylglycerol pathway. As well as in the brain, mGluR5s and their ligands have been found in peripheral organs, including those associated with the gastrointestinal (GI) tract. We review published findings about their identification and role in the mouth, esophagus, stomach and intestine and accessory digestive organs such as the tongue, liver and pancreas. We conclude that mGluR5s are still poorly studied in the GI tract and their peripheral non-synaptic signaling, and that their therapeutic potential needs to be further investigated.