Hu L, Li HL, Li WF, Chen JM, Yang JT, Gu JJ, Xin L. Clinical significance of expression of proliferating cell nuclear antigen and E-cadherin in gastric carcinoma. World J Gastroenterol 2017; 23(20): 3721-3729 [PMID: 28611525 DOI: 10.3748/wjg.v23.i20.3721]
Corresponding Author of This Article
Hong-lang Li, MD, Chief physician, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, East Lake District, Nanchang 330006, Jiangxi Province, China. lihonglang6802@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Prospective Study
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Hu L, Li HL, Li WF, Chen JM, Yang JT, Gu JJ, Xin L. Clinical significance of expression of proliferating cell nuclear antigen and E-cadherin in gastric carcinoma. World J Gastroenterol 2017; 23(20): 3721-3729 [PMID: 28611525 DOI: 10.3748/wjg.v23.i20.3721]
World J Gastroenterol. May 28, 2017; 23(20): 3721-3729 Published online May 28, 2017. doi: 10.3748/wjg.v23.i20.3721
Clinical significance of expression of proliferating cell nuclear antigen and E-cadherin in gastric carcinoma
Lin Hu, Hong-Lang Li, Wei-Feng Li, Jun-Min Chen, Jian-Tao Yang, Jun-Jing Gu, Lin Xin
Lin Hu, Hong-Lang Li, Wei-Feng Li, Jun-Min Chen, Jian-Tao Yang, Jun-Jing Gu, Lin Xin, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Author contributions: Hu L and Li HL designed the research, performed the research, and wrote the paper; Hu L, Li HL, Li WF, Chen JM, Yang JT, Gu JJ and Xin L contributed new reagents or analytic tools; Hu L, Li HL, Li WF, Chen JM and Yang JT analyzed the data; all authors approved the final version of the manuscript.
Supported bythe National Natural Science Foundation of China, No. 81360330.
Institutional review board statement: The study was reviewed and approved by the Second Affiliated Hospital of Nanchang University Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent to study enrollment.
Conflict-of-interest statement: we declare that there are no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Correspondence to: Hong-lang Li, MD, Chief physician, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, East Lake District, Nanchang 330006, Jiangxi Province, China. lihonglang6802@163.com
Telephone: +86-791-86312170 Fax: +86-791-86312170
Received: February 16, 2017 Peer-review started: February 16, 2017 First decision: March 14, 2017 Revised: March 27, 2017 Accepted: May 4, 2017 Article in press: May 4, 2017 Published online: May 28, 2017 Processing time: 100 Days and 8.1 Hours
Core Tip
Core tip: The expression of proliferating cell nuclear antigen (PCNA) and E-cadherin was detected by immunohistochemistry in gastric tissues of 186 patients. During the transition of normal gastric mucosa to gastric cancer, the PCNA labeling index gradually increased, while the E-cadherin labeling index gradually decreased (P < 0.05). There was a negative correlation between the expression of PCNA and E-cadherin in gastric carcinoma. High T stage and positive PCNA expression were risk factors for the prognosis of patients with gastric cancer (RR > 1), while the positive expression of E-cadherin was a protective factor (RR < 1). Combined detection of PCNA and E-cadherin can improve the accuracy of assessing the prognosis of patients with gastric cancer.
