Case Control Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2017; 23(19): 3480-3487
Published online May 21, 2017. doi: 10.3748/wjg.v23.i19.3480
Polymorphisms of microRNA target genes IL12B, INSR, CCND1 and IL10 in gastric cancer
Vytenis Petkevicius, Violeta Salteniene, Simonas Juzenas, Thomas Wex, Alexander Link, Marcis Leja, Ruta Steponaitiene, Jurgita Skieceviciene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Peter Malfertheiner, Juozas Kupcinskas
Vytenis Petkevicius, Violeta Salteniene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Department of Gastroenterology, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania
Simonas Juzenas, Ruta Steponaitiene, Jurgita Skieceviciene, Limas Kupcinskas, Laimas Jonaitis, Gediminas Kiudelis, Juozas Kupcinskas, Institute for Digestive Research, Lithuanian University of Health Sciences, 50009 Kaunas, Lithuania
Thomas Wex, Alexander Link, Peter Malfertheiner, Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, 39106 Magdeburg, Germany
Thomas Wex, Medical Laboratory for Clinical Chemistry, Microbiology and Infectious Diseases, Department of Molecular Genetics, Otto-von-Guericke University, 39106 Magdeburg, Germany
Marcis Leja, Institute for Clinical and Preventive Medicine, University of Latvia, 1586 Riga, Latvia
Marcis Leja, Faculty of Medicine, University of Latvia, 1586 Riga, Latvia
Marcis Leja, Riga East University Hospital, 1079 Riga, Latvia
Author contributions: Petkevicius V and Salteniene V contributed equally to this work; Wex T, Kupcinskas L, Malfertheiner P and Kupcinskas J designed the research; Juzenas S, Steponaitiene R, Skieceviciene J, Jonaitis L and Kiudelis G performed analysis and interpretation of data; Petkevicius V, Salteniene V and Kupcinskas J drafted the manuscript; Wex T, Link A, Leja M and Kupcinskas L provided critical revision of the manuscript for important intellectual content.
Supported by Lithuanian Research Council Grant, No. MIP-14418.
Institutional review board statement: The study was approved by the Ethics Committees of the Otto-von-Guericke University Magdeburg (Protocols No. 63/08 and No. 34/08), Lithuanian University of Health Sciences (Protocol No. BE-10-2) and Central Medical Ethics Committee of Latvia (Protocol No. 91-29.1/20 dated 22.09.2011).
Informed consent statement: All patients have signed an informed consent form to participate in the study.
Conflict-of-interest statement: The authors declare no conflicts.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Juozas Kupcinskas, MD, PhD, Gastroenterologist, Chief Researcher, Department of Gastroenterology, Lithuanian University of Health Sciences, Eiveniu str. 2, Kaunas 50009, Lithuania. juozas.kupcinskas@lsmuni.lt
Telephone: +370-37-326508
Received: December 23, 2016
Peer-review started: December 25, 2016
First decision: January 19, 2017
Revised: February 23, 2017
Accepted: March 21, 2017
Article in press: March 21, 2017
Published online: May 21, 2017
Processing time: 148 Days and 8.3 Hours
Core Tip

Core tip: Several studies have evaluated an association between single-nucleotide polymorphisms (SNPs) and gastric cancer (GC) risk. Here we used novel approach. Using bioinformatical analysis tools, several SNPs were identified as potential target sites of microRNAs that previously have been linked with gastric carcinogenesis. This study evaluated an association between SNPs in the INSR (rs1051690), IL12B (rs1368439), CCND1 (rs7177), and IL10 (rs3024498) genes and risk of GC in subjects of European descent. The study found that INSR rs1051690 SNP was associated with increased risk of GC, while polymorphisms in IL12B, CCND1 and IL10 genes showed no association with GC.