Hepatitis B virus infection and alcohol consumption

doi:10.3748/wjg.v23.i15.2651

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Apr 21, 2017; 23(15): 2651-2659
Published online Apr 21, 2017. doi: 10.3748/wjg.v23.i15.2651

Hepatitis B virus infection and alcohol consumption

Ayako Iida-Ueno, Masaru Enomoto, Akihiro Tamori, Norifumi Kawada

Ayako Iida-Ueno, Masaru Enomoto, Akihiro Tamori, Norifumi Kawada, Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan

Author contributions: Enomoto M generated the tables; Iida-Ueno A, Enomoto M, Tamori A and Kawada N wrote the manuscript.

Conflict-of-interest statement: Professor Norifumi Kawada has received grants from Bristol-Myers K.K. and Chugai Pharmaceutical Co., Ltd.

Correspondence to: Dr. Masaru Enomoto, Department of Hepatology, Graduate School of Medicine, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan. enomoto-m@med.osaka-cu.ac.jp

Telephone: +81-6-66453905 Fax: +81-6-66350915

Received: November 16, 2016
Peer-review started: November 16, 2016
First decision: December 19, 2016
Revised: January 25, 2017
Accepted: March 2, 2017
Article in press: March 2, 2017
Published online: April 21, 2017
Processing time: 155 Days and 6.1 Hours

Core Tip

Core tip: The mechanisms by which alcohol enhances disease progression are less well understood in chronic hepatitis B than in chronic hepatitis C. The association of light-to-moderate alcohol consumption with clinical outcomes in patients with chronic hepatitis B virus (HBV) infection appears modest. Although the threshold amount of alcohol for increasing hepatocellular carcinoma (HCC) risk remains unknown, heavy alcohol consumption significantly accelerates the progression of liver disease to cirrhosis and, ultimately, HCC. Alcohol abuse could impair the response to interferon-α therapy in chronic hepatitis B patients, although not fully confirmed, and can increase the risk of HCC even in patients with low HBV DNA levels during nucleoside/nucleotide therapy.