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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2017; 23(14): 2511-2518
Published online Apr 14, 2017. doi: 10.3748/wjg.v23.i14.2511
Published online Apr 14, 2017. doi: 10.3748/wjg.v23.i14.2511
Berberine displays antitumor activity in esophageal cancer cells in vitro
Shu-Xian Jiang, Bo Qi, Wen-Jian Yao, Cheng-Wei Gu, Xiu-Feng Wei, Yi Zhao, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China
Author contributions: Jiang SX and Qi B contributed equally to this work; Zhao Y, Liu YZ and Zhao BS contributed to study conception and design; Jiang SX, Qi B and Yao WJ designed the methods and performed the majority of experiments; Gu CW and Wei XF contributed to revision for intellectual content; Liu YZ interpreted the results and wrote the paper.
Supported by Key Technologies R&D Program of Science and Technology Commission of Henan Province , No. 52102310110 to Zhao BS ; and Key Science and Technique Fund of Xinxiang , No. ZG15018 to Zhao BS .
Institutional review board statement: This study was reviewed and approved by the First Affiliated Hospital of Xinxiang Medical University Institutional Review Board.
Conflict-of-interest statement: The authors declare that no conflict of interest exists in this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Bao-Sheng Zhao, MD, Professor, Chief, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China. zhaobscn@126.com
Telephone: +86-373-4404718 Fax: +86-373-4402573
Received: November 16, 2016
Peer-review started: November 17, 2016
First decision: December 19, 2016
Revised: January 6, 2017
Accepted: March 2, 2017
Article in press: March 2, 2017
Published online: April 14, 2017
Processing time: 149 Days and 8.1 Hours
Peer-review started: November 17, 2016
First decision: December 19, 2016
Revised: January 6, 2017
Accepted: March 2, 2017
Article in press: March 2, 2017
Published online: April 14, 2017
Processing time: 149 Days and 8.1 Hours
Core Tip
Core tip: Initial diagnosis of many esophageal cancer (EC) patients is made at an advanced stage of the disease, making surgery an undesirable option. Although advances in chemotherapy have been achieved, serious adverse effects usually limit clinical application. Exploring non-invasive strategies to prevent the growth of EC is urgently needed. The current research showed that berberine is an inhibitor of human EC cell growth and could be considered as a potential source of drugs for the treatment of EC patients.