©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2017; 23(14): 2453-2458
Published online Apr 14, 2017. doi: 10.3748/wjg.v23.i14.2453
Published online Apr 14, 2017. doi: 10.3748/wjg.v23.i14.2453
Noninvasive molecular analysis of Helicobacter pylori: Is it time for tailored first-line therapy?
Enzo Ierardi, Floriana Giorgio, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Antonio Pisani, Alfredo Di Leo, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy
Author contributions: Ierardi E, Giorgio F, Principi M and Di Leo A provided intellectual matter, revised the manuscript and approved the final version; Iannone A, Losurdo G, Barone M and Pisani A collected the data, wrote the first and revised the final version before approval.
Conflict-of-interest statement: The authors declare no conflict of interest.
Correspondence to: Enzo Ierardi, Professor, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy. e.ierardi@virgilio.it
Telephone: +39-08-05593088 Fax: +39-08-05593088
Received: December 16, 2016
Peer-review started: December 18, 2016
First decision: January 19, 2017
Revised: February 21, 2017
Accepted: March 20, 2017
Article in press: March 20, 2017
Published online: April 14, 2017
Processing time: 119 Days and 1.1 Hours
Peer-review started: December 18, 2016
First decision: January 19, 2017
Revised: February 21, 2017
Accepted: March 20, 2017
Article in press: March 20, 2017
Published online: April 14, 2017
Processing time: 119 Days and 1.1 Hours
Core Tip
Core tip: The main problem of Helicobacter pylori (H. pylori) infection management is linked to antibiotic resistances. They are due to point mutations in bacterial DNA. Polymerase chain reaction-based, culture-free techniques on gastric biopsy samples are accurate in finding minimal traces of genotypic resistant and hetero-resistant strains. The need for endoscopic procedure is the most important limit to their spread. Therefore, the further step has been the detection of point mutations in bacterial DNA fecal samples. There is increasing evidence of potential availability of noninvasive investigations able to detect H. pylori resistances to antibiotics, which may lead to tailored first-line therapies.