Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2017; 23(11): 2002-2011
Published online Mar 21, 2017. doi: 10.3748/wjg.v23.i11.2002
Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22
Ya-Hui Ni, Li-Juan Huo, Ting-Ting Li
Li-Juan Huo, Ya-Hui Ni, Ting-Ting Li, Department of Gastroenterology, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Author contributions: Ni YH contributed to the design, performance and analysis of the study, data interpretation, and preparation of the paper; Huo LJ provided experimental guidance, funding and equipment; Li TT participated in the experimental design and discussion of findings; all authors approved the final version of the article to be published.
Conflict-of-interest statement: The authors declare that no conflict of interest exists in this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Li-Juan Huo, MD, Department of Gastroenterology, First Hospital of Shanxi Medical University, 85 South JieFang Road, Taiyuan 030001, Shanxi Province, China. mymail5296@163.com
Telephone: +86-351-4639796 Fax: +86-351-4639796
Received: November 9, 2016
Peer-review started: November 13, 2016
First decision: December 19, 2016
Revised: January 7, 2017
Accepted: February 17, 2017
Article in press: February 17, 2017
Published online: March 21, 2017
Processing time: 129 Days and 23.7 Hours
Core Tip

Core tip: We successfully established an in vitro cell model of alcoholic liver fibrosis (ALF). We investigated the influence of interleukin (IL)-22 on ALF and the possible mechanism involved. To our knowledge, this is the first study to confirm the inhibitory effect of IL-22 on ALF at the cellular level. We found that the effect was at least partly related to promotion of nuclear translocation of nuclear factor-related factor (Nrf)2 and increased activity of the antioxidant axis Nrf2-keap1-ARE. We aimed to provide a new target for research on ALF and new drug development.