©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2017; 23(10): 1909-1919
Published online Mar 14, 2017. doi: 10.3748/wjg.v23.i10.1909
Published online Mar 14, 2017. doi: 10.3748/wjg.v23.i10.1909
Markers of systemic inflammation and colorectal adenoma risk: Meta-analysis of observational studies
Justyna Godos, Salvatore Sciacca, Giuseppe Grosso, Integrated Cancer Registry of Catania-Messina-Siracusa-Enna, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, 95123 Catania, Italy
Antonio Biondi, Francesco Basile, Department of General Surgery, Section of General Surgery and Oncology, University of Catania, 95123 Catania, Italy
Fabio Galvano, Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy
Edward L Giovannucci, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, United States
Edward L Giovannucci, Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, United States
Edward L Giovannucci, Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, United States
Author contributions: Godos J performed the search, the analysis, and wrote the manuscript; Biondi A, Galvano F, Basile F and Sciacca S provided critical revision; Giovannucci EL and Grosso G designed the study, and provided insights on methodology, data interpretation and manuscript drafting (equal contribution).
Conflict-of-interest statement: The authors deny any conflict of interest.
Data sharing statement: No additional data are available.
Correspondence to: Giuseppe Grosso, MD, PhD, Integrated Cancer Registry of Catania-Messina-Siracusa-Enna, Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele, 95123 Catania, Italy. giuseppe.grosso@studium.unict.it
Telephone: +39-95-3782110 Fax: +39-95-3782110
Received: December 11, 2016
Peer-review started: December 12, 2016
First decision: January 10, 2017
Revised: January 20, 2017
Accepted: February 16, 2017
Article in press: February 17, 2017
Published online: March 14, 2017
Processing time: 92 Days and 0.5 Hours
Peer-review started: December 12, 2016
First decision: January 10, 2017
Revised: January 20, 2017
Accepted: February 16, 2017
Article in press: February 17, 2017
Published online: March 14, 2017
Processing time: 92 Days and 0.5 Hours
Core Tip
Core tip: The present study investigated the association between inflammatory markers and risk of colorectal adenoma. Ten studies on C-reactive protein (CRP) showed non-significant summary odds ratios in the general analysis. However, CRP was significantly correlated with increased risk of advanced adenoma. Subgroup and stratified analyses revealed a potential influence of smoking status and aspirin use on the association between CRP levels and colorectal adenoma risk. The results of the study may have practical value for clinicians screening for colorectal cancer.