Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2017; 23(10): 1828-1835
Published online Mar 14, 2017. doi: 10.3748/wjg.v23.i10.1828
Experimental porcine model of complex fistula-in-ano
Ma-Mu-Ti-Jiang A Ba-Bai-Ke-Re, Hui Chen, Xue Liu, Yun-Hai Wang
Ma-Mu-Ti-Jiang A Ba-Bai-Ke-Re, Hui Chen, Xue Liu, Yun-Hai Wang, Department of Anorectal Surgery, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
Author contributions: A Ba-Bai-Ke-Re MMTJ contributed to study conception and design, and surgical technique (critically important intellectual content); Substantial contributions including research, study design, data source, recording, acquisition of data and final approval of the version to be published was carried out by Chen H and Liu X; analysis and interpretation of data was performed by Wang YH.
Supported by the National Natural Science Foundation of China, No. 81460133; Innovation program of regional cooperation of Xinjiang Autonomous Region, China, No. 2016E02063.
Institutional review board statement: This research was reviewed and approved by the Institutional Review Board of The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Institutional animal care and use committee statement: All procedures involving animals in this research were reviewed and approved by the Institutional Animal Care and Use Committee of the First Affiliated Hospital of Xinjiang Medical University, Urumqi, China (IACUC protocol number: 81460133).
Conflict-of-interest statement: The authors declared that there is no conflict of interest related to this research.
Data sharing statement: Technical appendix, statistical code, and dataset of this original article “Experimental Porcine Model of Fistula-In-Ano” is available from the corresponding author at mamutjan206@sina.com. We state that (1) we agree not to further share the data with others; (2) we will not permit the data to be used to set up any form of competing resource; and (3) we will not permit the supplied data to be used in support of any commercial activities.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ma-Mu-Ti-Jiang A Ba-Bai-Ke-Re, MD, PhD, Chief Physician, Professor, Department of Anorectal Surgery, First Affiliated Hospital, Xinjiang Medical University, 1 Liyushan Road, Urumqi 830011, Xinjiang Uygur Autonomous Region, China. mamutjan206@sina.com
Telephone: +86-135-79803435 Fax: +86-99-14366938
Received: October 26, 2016
Peer-review started: October 27, 2016
First decision: December 28, 2016
Revised: January 6, 2017
Accepted: January 18, 2017
Article in press: January 18, 2017
Published online: March 14, 2017
Processing time: 138 Days and 6.3 Hours
Core Tip

Core tip: Different new surgical methods for fistula-in-ano such as fibrin sealant or AFP plug should be used to establish animal models before a clinical trial begins. We established an experimental porcine anal fistula model using a rubber band ligation method which may provide a possible platform for anorectal fistula research. This surgical method using rubber band ligation is more stable and reliable than an artificial damage technique. Our porcine model of fistula-in-ano was confirmed by histopathology and anatomically similar to humans. This porcine model of fistula-in-ano can be used in the diagnosis and treatment of anal fistulas.