Marongiu F, Marongiu M, Contini A, Serra M, Cadoni E, Murgia R, Laconi E. Hyperplasia vs hypertrophy in tissue regeneration after extensive liver resection. World J Gastroenterol 2017; 23(10): 1764-1770 [PMID: 28348481 DOI: 10.3748/wjg.v23.i10.1764]
Corresponding Author of This Article
Fabio Marongiu, PhD, Experimental Medicine Unit, Department of Biomedical Sciences, University of Cagliari, Via Porcell 4, IV floor, 09124 Cagliari, Italy. fabiomarongiu@unica.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Fabio Marongiu, Michela Marongiu, Antonella Contini, Monica Serra, Erika Cadoni, Riccardo Murgia, Ezio Laconi, Experimental Medicine Unit, Department of Biomedical Sciences, University of Cagliari, 09124 Cagliari, Italy
Author contributions: Marongiu F, Marongiu M and Laconi E substantially contributed to the conception and design of the study, critical analysis and interpretation of data; all authors designed and performed the experiments, and contributed to the acquisition and analysis of data, made critical revisions related to the intellectual content of the manuscript, and approved the final version of the article to be published.
Supported byItalian Association for Cancer Research, No. IG 14640.
Institutional review board statement: The study was reviewed and approved by the University of Cagliari Institutional Review Board.
Institutional animal care and use committee statement: All animal studies described in this manuscript were reviewed and approved by the Institutional Animal Care and Use Committee of the University of Cagliari.
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Data sharing statement: No additional data are available.
Open Access:
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
Correspondence to: Fabio Marongiu, PhD, Experimental Medicine Unit, Department of Biomedical Sciences, University of Cagliari, Via Porcell 4, IV floor, 09124 Cagliari, Italy. fabiomarongiu@unica.it
Telephone: +39-70-6758683 Fax: +39-70-662574
Received: November 10, 2016 Peer-review started: November 13, 2016 First decision: December 19, 2016 Revised: December 27, 2016 Accepted: January 11, 2017 Article in press: January 11, 2017 Published online: March 14, 2017 Processing time: 122 Days and 23.7 Hours
Core Tip
Core tip: The ability of the liver to regenerate is remarkable on both clinical and biological grounds. It is still debated to what extent hypertrophy and hyperplasia contribute to liver mass restoration after major tissue loss. We addressed this issue using a genetically tagged system during the regenerative response elicited by 2/3 partial hepatectomy (PH) in rats. Analysis of cluster size distribution revealed that about half of the remnant hepatocytes completed at least 2 cell cycles. Average size of hepatocytes returned to control values throughout the regenerative process. Thus, hyperplasia stands as the major mechanism contributing to liver mass restoration after PH.
