Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2017; 23(1): 93-102
Published online Jan 7, 2017. doi: 10.3748/wjg.v23.i1.93
Role of mast cell-miR-490-5p in irritable bowel syndrome
Hai-Xia Ren, Fa-Can Zhang, He-Sheng Luo, Guo Zhang, Lie-Xin Liang
Hai-Xia Ren, He-Sheng Luo, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Fa-Can Zhang, Guo Zhang, Lie-Xin Liang, Department of Gastroenterology, Renmin Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Zhang FC, Luo HS, Zhang G and Liang LX designed this research; Ren HX performed the research; Ren HX, Zhang FC and Luo HS analyzed the data; Ren HX wrote the paper.
Supported by the National Natural Science Foundation of China, No. 81160053 (to Zhang FC).
Institutional review board statement: The study was reviewed and approved by the People’s Hospital of Wuhan University and People’s Hospital of Guangxi Zhuang Autonomous Region Institutional Review Board.
Conflict-of-interest statement: We declare that we have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: He-Sheng Luo, MD, Professor, Department of Gastroenterology, Renmin Hospital of Wuhan University, No. 238, Jiefang Road, Wuchang District, Wuhan 430060, Hubei Province, China. xhnk@163.com
Telephone: +86-27-97718831 Fax: +86-27-97718831
Received: July 13, 2016
Peer-review started: July 17, 2016
First decision: August 19, 2016
Revised: September 5, 2016
Accepted: September 14, 2016
Article in press: September 14, 2016
Published online: January 7, 2017
Processing time: 175 Days and 19.5 Hours
Core Tip

Core tip: Mast cells and mast cell degranulation play important roles in the pathophysiology of irritable bowel syndrome. miRNA is a class of important endogenous single-stranded non-coding RNA, and plays an essential regulatory role in complex biological systems without protein translation. In the present study, we aimed to determine the role of miR-490-5p in regulating mast cell proliferation and apoptosis, the expression of mast cell tryptase and PAR-2, and thus predict the role of miR-490-5p in the pathogenesis of irritable bowel syndrome.