©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2016; 22(48): 10592-10600
Published online Dec 28, 2016. doi: 10.3748/wjg.v22.i48.10592
Published online Dec 28, 2016. doi: 10.3748/wjg.v22.i48.10592
Risk stratification for malignant progression in Barrett’s esophagus: Gender, age, duration and year of surveillance
Piers Gatenby, Santanu Bhattacharjee, Christine Wall, Christine Caygill, Anthony Watson, United Kingdom Barrett’s Oesophagus Registry, UCL, NW32QG London, United Kingdom
Piers Gatenby, Regional Oesophagogastric Unit, Royal Surrey County Hospital, Guildford, GU2 7XH Surrey, United Kingdom
Piers Gatenby, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, GU2 7XH Surrey, United Kingdom
Piers Gatenby, Division of Surgery and Interventional Science, UCL, Royal Free Campus, NW32QG London, United Kingdom
Author contributions: All authors contributed to this manuscript with writing, designing, and final approval.
Supported by The Barrett’s Oesophagus Campaign ; The Wexham Gastrointestinal Trust ; The Childwick Trust, The R. L. St J. Harmsworth Memorial Research Fund ; and The David and Frederick Barclay Foundation .
Conflict-of-interest statement: None declared, the authors confirm that we have no financial arrangements related to the research or manuscript preparation to disclose.
Correspondence to: Piers Gatenby, MA MD FRCS, Division of Surgery and Interventional Science, UCL, Royal Free Campus, Pond Street, NW32QG London, United Kingdom. p.gatenby@ucl.ac.uk
Telephone: +44-20-76792000
Received: July 18, 2016
Peer-review started: July 20, 2016
First decision: September 20, 2016
Revised: October 17, 2016
Accepted: November 23, 2016
Article in press: November 28, 2016
Published online: December 28, 2016
Processing time: 160 Days and 23.7 Hours
Peer-review started: July 20, 2016
First decision: September 20, 2016
Revised: October 17, 2016
Accepted: November 23, 2016
Article in press: November 28, 2016
Published online: December 28, 2016
Processing time: 160 Days and 23.7 Hours
Core Tip
Core tip: Current surveillance guidelines for Barrett’s oesophagus base the enrolment into surveillance and surveillance interval on segment length, presence or absence of intestinal metaplasia and dysplasia. This study demonstrates the importance of age as an important risk factor for high-grade dysplasia and adenocarcinoma development and that stabilisation of the epithelium does not reliably occur at long-term follow-up.