©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2016; 22(46): 10219-10225
Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10219
Published online Dec 14, 2016. doi: 10.3748/wjg.v22.i46.10219
Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study
Marcelo Campos Appel-da-Silva, Suelen Aparecida da Silva Miozzo, Isabella de Azevedo Dossin, Cristiane Valle Tovo, Angelo Alves de Mattos, Graduate Program: Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS 900150-170, Brazil
Fernanda Branco, Ultrasound Imaging Service, Hospital Santa Casa de Porto Alegre, Porto Alegre, RS 90050-170, Brazil
Author contributions: All authors contributed to this paper with conception, drafting, revision, and approval of the final version of the manuscript.
Institutional review board statement: The study protocol was approved by the institutional review board for human studies at the Universidade Federal de Ciências da Saúde de Porto Alegre and complied with the guidelines of the Brazilian Ministry of Health.
Conflict-of-interest statement: The authors state no conflicts of interest. No financial support was provided for the study.
Data sharing statement: No additional data are available.
Correspondence to: Marcelo Campos Appel-da-Silva, MD, MSc, Graduate Program: Hepatology, Universidade Federal de Ciências da Saúde de Porto Alegre, Rua Dona Laura, 87/202, Porto Alegre, RS 900150-170, Brazil. marceloappel@yahoo.com.br
Telephone: +55-51-32225366 Fax: +55-51-32225366
Received: August 26, 2016
Peer-review started: August 29, 2016
First decision: September 20, 2016
Revised: October 4, 2016
Accepted: November 14, 2016
Article in press: November 16, 2016
Published online: December 14, 2016
Processing time: 108 Days and 15.6 Hours
Peer-review started: August 29, 2016
First decision: September 20, 2016
Revised: October 4, 2016
Accepted: November 14, 2016
Article in press: November 16, 2016
Published online: December 14, 2016
Processing time: 108 Days and 15.6 Hours
Core Tip
Core tip: This retrospective cohort chart review study provides novel data regarding the incidence of hepatocellular carcinoma (HCC) in the South of Brazil. Of 453 patients with cirrhosis attending a specialized reference clinic between March 2005 and March 2014, 75 (16.6%) developed HCC, with a cumulative incidence of 2.6%, 15.4% and 28.8% in the 1st, 5th, and 10th year respectively. Early-stage HCC was more often detected in patients undergoing strict surveillance every 6 mo. Results from this study highlight the need for strict surveillance programs favoring early diagnosis and, probably, a better prognosis.