©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2016; 22(44): 9775-9783
Published online Nov 28, 2016. doi: 10.3748/wjg.v22.i44.9775
Published online Nov 28, 2016. doi: 10.3748/wjg.v22.i44.9775
Naringenin protects against isoniazid- and rifampicin-induced apoptosis in hepatic injury
Chao Wang, Yan-Xiang Zhang, Hao Nie, Kan Li, Department of Laboratory Medicine, Medical School, Yangtze University, Jingzhou 434023, Hubei Province, China
Chao Wang, Hao Nie, Clinical and Molecular Immunology Research Center, Yangtze University, Jingzhou 434023, Hubei Province, China
Rui-Qin Fan, Department of Hepatic Disease, the Second Hospital of Jingzhou, Jingzhou 434000, Hubei Province, China
Author contributions: Wang C and Fan RQ contributed equally to this work; Wang C designed the research and revised the manuscript; Fan RQ performed the experiments, analyzed the data and wrote the manuscript; Zhang YX, Nie H and Li K established the animal model and collected the data.
Supported by National Natural Science Foundation of China , No. 31502059 ; Education Department of Hubei Province , No. B2016039 ; Medical School of Yangtze University , No. YXYQ201406 ; and Clinical and Molecular Immunology Research Center of Yangtze University .
Institutional review board statement: This study was reviewed and approved by the Medical School of Yangtze University.
Institutional animal care and use committee statement: All procedures were approved by the Institutional Animal Care and Use Committee (IACUC) of Yangtze University (Approval No. 20150148).
Conflict-of-interest statement: The authors report no conflicts of interest.
Data sharing statement: No additional data are available.
Correspondence to: Dr. Chao Wang, Associate Professor, Department of Laboratory Medicine, Medical School, Yangtze University, 1 Nanhuan Road, Jingzhou 434023, Hubei Province, China. celful60@163.com
Telephone: +86-716-8062635 Fax: +86-716-8062635
Received: July 4, 2016
Peer-review started: July 6, 2016
First decision: August 29, 2016
Revised: September 11, 2016
Accepted: September 28, 2016
Article in press: September 28, 2016
Published online: November 28, 2016
Processing time: 144 Days and 22.8 Hours
Peer-review started: July 6, 2016
First decision: August 29, 2016
Revised: September 11, 2016
Accepted: September 28, 2016
Article in press: September 28, 2016
Published online: November 28, 2016
Processing time: 144 Days and 22.8 Hours
Core Tip
Core tip: Anti-tuberculosis drugs can cause drug-induced liver injury through a series of complex mechanisms. The main purposes of the study were to explore the effects of naringenin (NRG) on liver injury induced by isoniazid (INH) and rifampicin (RIF). Mice were administered intragastrically with NRG before INH and RIF challenge. The findings revealed that NRG protects against INH- and RIF-induced oxidative stress and hepatocyte apoptosis.