Endocrine manifestations in celiac disease

Core Tip

Core tip: Celiac disease (CD) is an immune-mediated intestinal disorder that may be closely linked to a number of extra-intestinal disorders, particularly endocrine diseases. These include thyroiditis, particularly in adults, and insulin-dependent diabetes mellitus, particularly in children and adolescents. Other endocrine disorders have also been recorded, including adrenal insufficiency and pituitary disease. Usually, only a single endocrine gland is involved in CD, but changes in multiple different glands has also been recorded. If an endocrine disorder is present, screening for CD, even without gastrointestinal symptoms, has been recommended. In established CD, regular follow-up and evaluation for the possible appearance of an occult endocrine disorder may also be appropriate.