©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 14, 2016; 22(38): 8459-8471
Published online Oct 14, 2016. doi: 10.3748/wjg.v22.i38.8459
Published online Oct 14, 2016. doi: 10.3748/wjg.v22.i38.8459
Towards a new paradigm of microscopic colitis: Incomplete and variant forms
Danila Guagnozzi, Department of Gastroenterology, Hospital Universitario Vall d’Hebron, 08035 Barcelona, Spain
Stefania Landolfi, Department of Pathology, Hospital Universitario Vall d’Hebron, 08035 Barcelona, Spain
Maria Vicario, Translational Mucosal Immunology Lab, Digestive Diseases Research Unit, Vall d’Hebron Institut de Recerca, Department of Gastroenterology. Hospital Universitario Vall d’Hebron, Universitat Autónoma de Barcelona, 08035 Barcelona, Spain
Maria Vicario, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08035 Barcelona, Spain
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Supported by Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Subdirección General de Investigación Sanitaria, Ministerio de Economía y Competitividad, CP10/00502, PI13/00935 and CIBERehd, CB06/04/0021 (MV) .
Conflict-of-interest statement: No potential conflicts of interest. No specific financial support.
Correspondence to: Danila Guagnozzi, MD, Department of Gastroenterology, Hospital Universitario Vall d’Hebron, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain. danila_g@libero.it
Telephone: +34-934894035 Fax: + 34-934894032
Received: May 29, 2016
Peer-review started: May 30, 2016
First decision: July 13, 2016
Revised: August 20, 2016
Accepted: September 8, 2016
Article in press: September 8, 2016
Published online: October 14, 2016
Processing time: 136 Days and 8.5 Hours
Peer-review started: May 30, 2016
First decision: July 13, 2016
Revised: August 20, 2016
Accepted: September 8, 2016
Article in press: September 8, 2016
Published online: October 14, 2016
Processing time: 136 Days and 8.5 Hours
Core Tip
Core tip: Microscopic colitis (MC) includes two well-defined entities: collagenous colitis and lymphocytic colitis. Similar clinical manifestations, but variable histopathologic features have also been identified and recognized as additional forms of MC, as not all patients suffering from colitis fulfill the criteria for MC diagnosis. Introducing the histological diagnosis for incomplete MC subtypes could reduce the risk of missing patients with a treatable cause of chronic diarrhoea. The importance of developing research studies addressed at describing etiopathogenic mechanisms of MC subtypes is highlighted in this review.