©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2016; 22(35): 8010-8016
Published online Sep 21, 2016. doi: 10.3748/wjg.v22.i35.8010
Published online Sep 21, 2016. doi: 10.3748/wjg.v22.i35.8010
Liver grafts from hepatitis B surface antigen-positive donors: A review of the literature
Elisabetta Loggi, Fabio Conti, Alessandro Cucchetti, Giorgio Ercolani, Antonio Daniele Pinna, Pietro Andreone, Dipartimento di Scienze Mediche e Chirurgiche, Università degli Studi di Bologna, 40138 Bologna, Italy
Pietro Andreone, Centro di Ricerca per lo Studio delle Epatiti, Università degli Studi di Bologna, 40138 Bologna, Italy
Author contributions: Loggi E and Conti F performed the literature search; Loggi E drafted the paper; Conti F, Cucchetti A and Ercolani G analyzed and interpreted the data; Pinna AD revised the paper critically for important intellectual content; and Andreone P designed the work and corrected the final version.
Conflict-of-interest statement: Nothing to declare.
Correspondence to: Pietro Andreone, MD, Professor of Internal Medicine, Dipartimento di Scienze Mediche e Chirurgiche, Università degli Studi di Bologna, Via Massarenti, 9, 40138 Bologna, Italy. pietro.andreone@unibo.it
Telephone: +39-51-2143618 Fax: +39-51-345806
Received: March 26, 2016
Peer-review started: March 26, 2016
First decision: May 12, 2016
Revised: June 6, 2016
Accepted: July 21, 2016
Article in press: July 21, 2016
Published online: September 21, 2016
Processing time: 173 Days and 0.4 Hours
Peer-review started: March 26, 2016
First decision: May 12, 2016
Revised: June 6, 2016
Accepted: July 21, 2016
Article in press: July 21, 2016
Published online: September 21, 2016
Processing time: 173 Days and 0.4 Hours
Core Tip
Core tip: Organ shortage is the main problem of liver transplantation, and the use of marginal grafts could increase the donor pool. Data accumulated to date show that hepatitis B surface antigen-positive grafts could be an additional organ source for liver transplantation. The requirements that have to be fulfilled are the lack of a significant hepatitis B virus-disease of the graft, and the use of a proper prophylactic regimen, which is now largely available.