Chianello Nicolau M, Pinto LFR, Nicolau-Neto P, de Pinho PRA, Rossini A, de Almeida Simão T, Soares Lima SC. Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value. World J Gastroenterol 2016; 22(31): 7146-7156 [PMID: 27610024 DOI: 10.3748/wjg.v22.i31.7146]
Corresponding Author of This Article
Sheila Coelho Soares Lima, PhD, Researcher, Programa de Carcinogênese Molecular, Instituto Nacional de Câncer, Coordenação de Pesquisa, Rua André Cavalcanti, 37 - 6º andar, Bairro de Fátima, Rio de Janeiro 20231-050, Brazil. sheilacoelho@gmail.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Cohort Study
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Chianello Nicolau M, Pinto LFR, Nicolau-Neto P, de Pinho PRA, Rossini A, de Almeida Simão T, Soares Lima SC. Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value. World J Gastroenterol 2016; 22(31): 7146-7156 [PMID: 27610024 DOI: 10.3748/wjg.v22.i31.7146]
World J Gastroenterol. Aug 21, 2016; 22(31): 7146-7156 Published online Aug 21, 2016. doi: 10.3748/wjg.v22.i31.7146
Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value
Marina Chianello Nicolau, Luis Felipe Ribeiro Pinto, Pedro Nicolau-Neto, Paulo Roberto Alves de Pinho, Ana Rossini, Tatiana de Almeida Simão, Sheila Coelho Soares Lima
Marina Chianello Nicolau, Luis Felipe Ribeiro Pinto, Ana Rossini, Tatiana de Almeida Simão, Departamento de Bioquímica, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-013, Brazil
Marina Chianello Nicolau, Luis Felipe Ribeiro Pinto, Pedro Nicolau-Neto, Sheila Coelho Soares Lima, Programa de Carcinogênese Molecular, Instituto Nacional de Câncer, Coordenação de Pesquisa, Rio de Janeiro 20231-050, Brazil
Paulo Roberto Alves de Pinho, Gastroenterologia, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro 20551-013, Brazil
Author contributions: Chianello Nicolau M performed all experiments; Chianello Nicolau M, Nicolau-Neto P, de Pinho PRA and Rossini A collected materials and clinical data from patients and healthy individuals; de Almeida Simão T and Soares Lima SC designed and coordinated the research study; Chianello Nicolau M analyzed the data; Chianello Nicolau M, Pinto LFR, de Almeida Simão T and Soares Lima SC wrote the manuscript; Pinto LFR and Soares Lima SC provided financial support for the research.
Supported byConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Ministério da Saúde (INCA) and Swiss Bridge Foundation.
Institutional review board statement: This research study was approved by the Ethics Committee in Research of Hospital Universitário Pedro Ernesto (CEP/HUPE, 416) and by the Ethics Committee in Research of Instituto Nacional de Câncer (CEP-INCA, 116/11).
Informed consent statement: Informed consent was obtained from all individuals included in the study.
Conflict-of-interest statement: The authors state no conflict of interest.
Data sharing statement: No additional data are available.
Correspondence to: Sheila Coelho Soares Lima, PhD, Researcher, Programa de Carcinogênese Molecular, Instituto Nacional de Câncer, Coordenação de Pesquisa, Rua André Cavalcanti, 37 - 6º andar, Bairro de Fátima, Rio de Janeiro 20231-050, Brazil. sheilacoelho@gmail.com
Telephone: +55-21-32076596 Fax: +55-21-32076509
Received: February 12, 2016 Peer-review started: February 12, 2016 First decision: March 21, 2016 Revised: April 15, 2016 Accepted: May 4, 2016 Article in press: May 4, 2016 Published online: August 21, 2016 Processing time: 185 Days and 7.3 Hours
Core Tip
Core tip: Esophageal squamous cell carcinoma (ESCC) is the main histological subtype of esophageal cancer, and is associated with alcohol and tobacco consumption. Tobacco components, such as nicotine and nitrosamines, are high-affinity agonists of nicotinic cholinergic receptors (CHRNs), the activation of which triggers cellular signaling pathways important for cancer progression. However, data regarding differential expression and regulation of CHRNs in healthy esophageal mucosa and ESCC are limited. This study shows homogeneous expression of CHRNs along healthy esophagus and deregulation in ESCC, CHRNB4 overexpression preceding the first histopathological alterations during ESCC development, and CHRNA5 expression as an independent predictor of prognosis.
