Hepatitis C virus - associated B cell non-Hodgkin's lymphoma

doi:10.3748/wjg.v22.i27.6214

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World Journal of Gastroenterology

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World J Gastroenterol. Jul 21, 2016; 22(27): 6214-6223
Published online Jul 21, 2016. doi: 10.3748/wjg.v22.i27.6214

Hepatitis C virus - associated B cell non-Hodgkin's lymphoma

Romeo-Gabriel Mihăilă

Romeo-Gabriel Mihăilă, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 500169 Sibiu, Romania

Romeo-Gabriel Mihăilă, Hematology Department, Emergency County Clinical Hospital Sibiu, 550245 Sibiu, Romania

Author contributions: Mihăilă RG solely contributed to this manuscript.

Conflict-of-interest statement: The author has no conflict of interest associated with this manuscript.

Correspondence to: Romeo-Gabriel Mihăilă, MD, PhD, Professor, Chief, Hematology Department, Emergency County Clinical Hospital Sibiu, Bulevardul Corneliu Coposu 2-4, 550245 Sibiu, Romania. romeomihaila@yahoo.com

Telephone: +40-269-215050 Fax: +40-269-218365

Received: March 26, 2016
Peer-review started: March 26, 2016
First decision: May 12, 2016
Revised: May 13, 2016
Accepted: June 15, 2016
Article in press: June 15, 2016
Published online: July 21, 2016
Processing time: 111 Days and 13.7 Hours

Core Tip

Core tip: There are epidemiological observations on the association between hepatitis C virus (HCV) infection and non-Hodgkin's lymphoma. Various microenvironmental signals, such as cytokines, viral antigenic external stimulation of lymphocyte receptors by HCV antigens, and intercellular interactions contribute to B cell proliferation. HCV lymphotropism and chronic antigenic stimulation are involved in B-lymphocyte expansion, as mixted cryoglobulinemia or monoclonal gammopathy of undetermined significance, which can progress to B cell non-Hodgkin's lymphoma (BCNHL). HCV infected patients with indolent BCNHL who receive antiviral therapy can be potentially cured. Viral clearance was related to lymphoma response, fact that highlights the probable involvement of HCV in lymphomagenesis.