Retrospective Cohort Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2016; 22(26): 6049-6056
Published online Jul 14, 2016. doi: 10.3748/wjg.v22.i26.6049
Development and validation of a risk score for advanced colorectal adenoma recurrence after endoscopic resection
Antonio Facciorusso, Marianna Di Maso, Gaetano Serviddio, Gianluigi Vendemiale, Nicola Muscatiello
Antonio Facciorusso, Marianna Di Maso, Nicola Muscatiello, Gastroenterology Unit, University of Foggia, 71100 Foggia, Italy
Gaetano Serviddio, Gianluigi Vendemiale, Internal Medicine Unit, University of Foggia, 71100 Foggia, Italy
Author contributions: Facciorusso A designed the study, performed the statistical analysis and wrote the paper; Muscatiello N and Di Maso M performed the treatment procedures and collected the data; Vendemiale G and Serviddio G revised the paper.
Institutional review board statement: This study was approved by the Institutional Review Board of the University of Foggia for retrospective evaluation of de-identified patients.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: None of the authors have received fees for serving as a speaker or are consultant/advisory board member for any organizations. None of the authors have received research funding from any organizations. None of the authors are employees of any organizations. None of the authors own stocks and/or share in any organizations. None of the authors own patents.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Antonio Facciorusso, MD, Gastroenterology Unit, Department of Medical Sciences, University of Foggia, Viale L.Pinto, 1, 71100 Foggia, Italy. antonio.facciorusso@virgilio.it
Telephone: +39-881-732154 Fax: +39-881-732135
Received: February 28, 2016
Peer-review started: February 29, 2016
First decision: March 31, 2016
Revised: April 1, 2016
Accepted: April 20, 2016
Article in press: April 20, 2016
Published online: July 14, 2016
Processing time: 128 Days and 21.6 Hours
Core Tip

Core tip: This is a retrospective study to develop and validate a novel risk score aimed at predicting advanced colorectal adenoma (ACA) recurrence after endoscopic polypectomy. The score based on lesion size, number of ACAs and grade of dysplasia, considering 5 as cut-off point, defined two different risk groups: high-risk group (score ≥ 5) with a 3-year recurrence rate of 47.6% and low-risk group (score < 5) with a 3-year recurrence rate of 7.9%. Further evidence, provided by large randomized controlled trials, is necessary in order to completely address this important issue.