Pancreatic cancer stem cell markers and exosomes - the incentive push

doi:10.3748/wjg.v22.i26.5971

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 22, Issue 26

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (25772)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-6) series.

Item

Count

PDF

2087

WORD

666

HTML

17926

Figures (1-6)

668

Sum=21347

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1524

Download

2901

Sum=4425

Jul 14, 2016 (publication date) through May 1, 2026

Times Cited of This Article

Times Cited (78)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article with Cover (PDF)
- Full Article (XML)

Review

World J Gastroenterol. Jul 14, 2016; 22(26): 5971-6007
Published online Jul 14, 2016. doi: 10.3748/wjg.v22.i26.5971

Pancreatic cancer stem cell markers and exosomes - the incentive push

Sarah Heiler, Zhe Wang, Margot Zöller

Sarah Heiler, Zhe Wang, Margot Zöller, Tumor Cell Biology, University Hospital of Surgery, D 69120 Heidelberg, Germany

Author contributions: Zöller M wrote the first draft and the final version; Heiler S and Wang Z contributed to writing and final version approving.

Supported by Wilhelm Sander Stiftung to Zöller M, No. 2009.100.2; German Cancer Research Aid to Zöller M, No. 110836; and China Scholarship Council to Wang Z, CSC 201408080067.

Conflict-of-interest statement: The authors declare no conflict of interest.

Correspondence to: Dr. Margot Zöller, Tumor Cell Biology, University Hospital of Surgery, Im Neuenheimer Feld 365, D 69120 Heidelberg, Germany. m.zoeller@uni-hd.de

Telephone: +49-6210-565146 Fax: +49-6210-565199

Received: March 19, 2016
Peer-review started: March 22, 2016
First decision: May 30, 2016
Revised: June 3, 2016
Accepted: June 28, 2016
Article in press: June 28, 2016
Published online: July 14, 2016
Processing time: 109 Days and 10.9 Hours

Core Tip

Core tip: Cancer progression relies on a small population of cancer stem cells (CSC), characterized by longevity, self renewal, drug resistance and requirement of a niche. In addition, CSC abundantly deliver exosomes (TEX) allowing CSC a long distance communication. At the descriptive level, CSC are characterized by a set of so called CSC markers. We here discuss for pancreatic cancer that the CSC markers CD44v6, c-Met, Tspan8, alpha6beta4, EpCAM, claudin7, CXCR4 and prominin1 can in a concerted activity account for all CSC features. This includes CSC TEX activity due to the engagement of CSC markers in TEX biogenesis and enrichment in TEX.

Heiler S, Wang Z, Zöller M. Pancreatic cancer stem cell markers and exosomes - the incentive push. World J Gastroenterol 2016; 22(26): 5971-6007 [PMID: 27468191 DOI: 10.3748/wjg.v22.i26.5971]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.