Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2016; 22(22): 5183-5192
Published online Jun 14, 2016. doi: 10.3748/wjg.v22.i22.5183
miR-106b promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma
Chia-Sheng Yen, Zhi-Ru Su, Yi-Ping Lee, I-Ting Liu, Chia-Jui Yen
Chia-Sheng Yen, Institute of Clinical Medicine, National Cheng Kung University, Tainan 70101, Taiwan
Chia-Sheng Yen, Department of General Surgery, Chi Mei Medical Center, Tainan 71004, Taiwan
Zhi-Ru Su, Yi-Ping Lee, I-Ting Liu, Chia-Jui Yen, Division of Hematology and Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan
Author contributions: Yen CS and Yen CJ designed the study; Su ZR performed the experiments; Lee YP, Su ZR and Liu IT analyzed the data; Liu IT collected the clinical samples; Yen CS, Lee YP, Su ZR and Yen CJ drafted the manuscript.
Supported by National Cheng Kung University Hospital Research Fund, No. NCKUH-10103002.
Institutional review board statement: This study was reviewed and approved through the National Cheng Kung University Hospital Institutional Review Board.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chia-Jui Yen, MD, PhD, Associate Professor, Division of Hematology and Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70403, Taiwan. yencj@mail.ncku.edu.tw
Telephone: +886-6-2353535 Fax: +886-6-2752037
Received: January 27, 2016
Peer-review started: January 28, 2016
First decision: March 7, 2016
Revised: March 24, 2016
Accepted: April 7, 2016
Article in press: April 7, 2016
Published online: June 14, 2016
Processing time: 126 Days and 23.9 Hours
Core Tip

Core tip: The role of miR-106b in tumor progression of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) and how it be regulated are still unclear. In this study, we analyzed the expression levels of miR-106b in HBV-associated HCC tissues and correlated the data with clinical records of patients. Our results indicated that miR-106b expression was up-regulated and related with tumor progression in HBV-associated HCC. In addition, hepatitis B virus X protein may contribute to enhance the transcription of miR-106b. These findings provide potential diagnostic and therapeutic targets for HBV-associated HCC.