Observational Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2016; 22(20): 4918-4925
Published online May 28, 2016. doi: 10.3748/wjg.v22.i20.4918
Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function
Madhusudhan R Sanaka, Umar Hayat, Prashanthi N Thota, Ramprasad Jegadeesan, Monica Ray, Scott L Gabbard, Neha Wadhwa, Rocio Lopez, Mark E Baker, Sudish Murthy, Siva Raja
Madhusudhan R Sanaka, Umar Hayat, Prashanthi N Thota, Ramprasad Jegadeesan, Monica Ray, Scott L Gabbard, Neha Wadhwa, Rocio Lopez, Department of Gastroenterology, Q3 Cleveland Clinic, Cleveland, OH 44195, United States
Mark E Baker, Department of Radiology, Cleveland Clinic, Cleveland, OH 44195, United States
Sudish Murthy, Siva Raja, Department of Cardiothoracic Surgery, Cleveland Clinic, Cleveland, OH 44195, United States
Author contributions: Sanaka MR designed the study, acquired data and wrote the manuscript; Hayat U, Thota PN, Jegadeesan R, Ray M, Gabbard SL, Wadhwa N, Baker ME, Murthy S and Raja S contributed equally to the study, acquired the data and reviewed the manuscript; Lopez R designed the study, analyzed the data and reviewed the manuscript; All authors approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by Cleveland Clinic Institutional Review Board.
Informed consent statement: All patients provided written informed consent prior to their treatments.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Madhusudhan R Sanaka, MD, FACG, FASGE, Department of Gastroenterology, Q3 Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, United States. sanakam@ccf.org
Telephone: +1-216-4443423 Fax: +1-216-4446284
Received: February 14, 2016
Peer-review started: February 14, 2016
First decision: March 21, 2016
Revised: March 26, 2016
Accepted: April 7, 2016
Article in press: April 7, 2016
Published online: May 28, 2016
Processing time: 95 Days and 14.5 Hours
Core Tip

Core tip: This study evaluated and compared the efficacy of peroral endoscopic myotomy with laparoscopic Heller myotomy and pneumatic dilation in improving esophageal function in achalasia. Esophageal function was objectively assessed by timed barium esophagram and high resolution manometry at 2 mo follow-up. The results demonstrate that all three treatment modalities are effective in improving esophageal function at short term follow-up and there was no difference in efficacy between the three treatment modalities.