Gulbake A, Jain A, Jain A, Jain A, Jain SK. Insight to drug delivery aspects for colorectal cancer. World J Gastroenterol 2016; 22(2): 582-599 [PMID: 26811609 DOI: 10.3748/wjg.v22.i2.582]
Corresponding Author of This Article
Sanjay K Jain, Professor, Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar 470003, Madhya Pradesh, India. drskjainin@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Arvind Gulbake, Center for Interdisciplinary Research, D.Y. Patil University, Kolhapur 416006, Maharashtra, India
Aviral Jain, Pharmaceutics Research Laboratory, Department of Pharmaceutics, Ravishankar College of Pharmacy, Bhopal 462010, Madhya Pradesh, India
Ashish Jain, Ankit Jain, Sanjay K Jain, Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar 470003, Madhya Pradesh, India
Author contributions: All the authors contributed to this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sanjay K Jain, Professor, Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar 470003, Madhya Pradesh, India. drskjainin@yahoo.com
Telephone: +91-7582-265457
Received: April 29, 2015 Peer-review started: May 11, 2015 First decision: June 25, 2015 Revised: August 29, 2015 Accepted: November 30, 2015 Article in press: December 1, 2015 Published online: January 14, 2016 Processing time: 252 Days and 14.6 Hours
Core Tip
Core tip: Colorectal cancer (CRC) is one the major worldwide health problems owing to its high prevalence and mortality rates. It is reported that over 40000 of the adult United Kingdom population are diagnosed with CRC each year. In case of early diagnosis CRC is also one of the most curable types of cancer (cure rates > 90%). This article gives an overview study of causes and etiology of colon cancer, distinct stages from stage from 0 to IV, some novel therapies are also briefly discussed in article such as receptor (epidermal growth factor receptor, folate receptor, wheat germ agglutinin, VEGF receptor, hyaluronic acid receptor) based targeting therapy; colon targeted proapoptotic anticancer drug delivery system, gene therapy. Recent developments in screening, prevention, biomarker and genomic analysis, nutritional supplement therapy, vaccination, and chemotherapy have improved detection and significant reduction in mortality statistics.
