Insight to drug delivery aspects for colorectal cancer

doi:10.3748/wjg.v22.i2.582

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Jan 14, 2016 (publication date) through Feb 27, 2026

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Topic Highlight

World J Gastroenterol. Jan 14, 2016; 22(2): 582-599
Published online Jan 14, 2016. doi: 10.3748/wjg.v22.i2.582

Insight to drug delivery aspects for colorectal cancer

Arvind Gulbake, Aviral Jain, Ashish Jain, Ankit Jain, Sanjay K Jain

Arvind Gulbake, Center for Interdisciplinary Research, D.Y. Patil University, Kolhapur 416006, Maharashtra, India

Aviral Jain, Pharmaceutics Research Laboratory, Department of Pharmaceutics, Ravishankar College of Pharmacy, Bhopal 462010, Madhya Pradesh, India

Ashish Jain, Ankit Jain, Sanjay K Jain, Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar 470003, Madhya Pradesh, India

Author contributions: All the authors contributed to this manuscript.

Correspondence to: Sanjay K Jain, Professor, Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar 470003, Madhya Pradesh, India. drskjainin@yahoo.com

Telephone: +91-7582-265457

Received: April 29, 2015
Peer-review started: May 11, 2015
First decision: June 25, 2015
Revised: August 29, 2015
Accepted: November 30, 2015
Article in press: December 1, 2015
Published online: January 14, 2016
Processing time: 252 Days and 14.6 Hours

Core Tip

Core tip: Colorectal cancer (CRC) is one the major worldwide health problems owing to its high prevalence and mortality rates. It is reported that over 40000 of the adult United Kingdom population are diagnosed with CRC each year. In case of early diagnosis CRC is also one of the most curable types of cancer (cure rates > 90%). This article gives an overview study of causes and etiology of colon cancer, distinct stages from stage from 0 to IV, some novel therapies are also briefly discussed in article such as receptor (epidermal growth factor receptor, folate receptor, wheat germ agglutinin, VEGF receptor, hyaluronic acid receptor) based targeting therapy; colon targeted proapoptotic anticancer drug delivery system, gene therapy. Recent developments in screening, prevention, biomarker and genomic analysis, nutritional supplement therapy, vaccination, and chemotherapy have improved detection and significant reduction in mortality statistics.