©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2016; 22(18): 4446-4458
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4446
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4446
Advances in inducing adaptive immunity using cell-based cancer vaccines: Clinical applications in pancreatic cancer
Mikio Kajihara, Kazuki Takakura, Tomoya Kanai, Zensho Ito, Yoshihiro Matsumoto, Toshifumi Ohkusa, Shigeo Koido, Division of Gastroenterology and Hepatology, Department of Internal Medicine, the Jikei University School of Medicine (Kashiwa Hospital), Chiba 277-8567, Japan
Shigetaka Shimodaira, Cell Processing Center, Shinshu University Hospital, Nagano 390-8621, Japan
Masato Okamoto, Department of Advanced Immunotherapeutics, Kitasato University School of Pharmacy, Tokyo 108-8641, Japan
Toshifumi Ohkusa, Shigeo Koido, Institute of Clinical Medicine and Research, The Jikei University School of Medicine, Chiba 277-8567, Japan
Author contributions: Kajihara M, Takakura K, Kanai T, Ito Z, Matsumoto Y, Shimodaira S, Okamoto M, Ohkusa T and Koido S designed the manuscript; Koido S wrote the paper; Kajihara M, Takakura K and Koido S contributed equally to this manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Correspondence to: Shigeo Koido, MD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, the Jikei University School of Medicine (Kashiwa Hospital), 163-1 Kashiwashita, Kashiwa, Chiba 277-8567, Japan. shigeo_koido@jikei.ac.jp
Telephone: +81-4-71641111 Fax: +81-4-71633488
Received: January 14, 2016
Peer-review started: January 16, 2016
First decision: March 21, 2016
Revised: April 1, 2016
Accepted: April 15, 2016
Article in press: April 15, 2016
Published online: May 14, 2016
Processing time: 110 Days and 22.3 Hours
Peer-review started: January 16, 2016
First decision: March 21, 2016
Revised: April 1, 2016
Accepted: April 15, 2016
Article in press: April 15, 2016
Published online: May 14, 2016
Processing time: 110 Days and 22.3 Hours
Core Tip
Core tip: Chemotherapy and cell-based cancer vaccines such as dendritic cell- and whole tumor cell-based cancer vaccines can synergize to result in increased efficacies in patients with pancreatic ductal adenocarcinoma (PDA). Moreover, cell-based cancer vaccines and immune checkpoint inhibitors can be used to block inhibitory ligand/receptor interactions by acting on certain cancer cells or T cells, allowing an enhancement of the antitumor immune response in specific tumors, including PDA. Therefore, the blockade of immune regulatory checkpoints combined with cell-based cancer vaccines and/or chemotherapy may be effective in inducing adaptive antitumor immunity in patients with PDA.