Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study

doi:10.3748/wjg.v22.i16.4191

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Retrospective Study

World J Gastroenterol. Apr 28, 2016; 22(16): 4191-4200
Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4191

Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study

I Jane Cox, Abil E Aliev, Mary ME Crossey, Mahvish Dawood, Mamun Al-Mahtab, Sheikh M Akbar, Salimur Rahman, Antonio Riva, Roger Williams, Simon D Taylor-Robinson

I Jane Cox, Antonio Riva, Roger Williams, Institute of Hepatology, London, Foundation for Liver Research, London WC1E 6HX, United Kingdom

Abil E Aliev, Department of Chemistry, University College London, London WC1H 0AJ, United Kingdom

Mary ME Crossey, Mahvish Dawood, Simon D Taylor-Robinson, Division of Digestive Diseases, Department of Surgery and Cancer, Imperial College London, London W2 1NY, United Kingdom

Mamun Al-Mahtab, Salimur Rahman, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000, Bangladesh

Sheikh M Akbar, Department of Medical Sciences, Toshiba General Hospital, Tokyo 140-8522, Japan

Author contributions: Cox IJ, Williams R, Taylor-Robinson SD, Al-Mahtab M, Rahman S and Akbar SM designed the research; Cox IJ, Crossey MME, Dawood M and Aliev AE performed the research; Cox IJ, Aliev AE, Dawood M and Riva A analyzed the data; Riva A provided statistical advice; Cox IJ, Taylor-Robinson SD, Al-Mahtab M and Williams R wrote the paper.

Institutional review board statement: Ethical approval was granted by the research ethics committee at Bangabandhu Sheikh Mujib Medical University and Imperial College London (REC 09/H0712/82).

Informed consent statement: Informed consent was obtained from the study participants

Conflict-of-interest statement: To the best of our knowledge the authors declare no conflict of interest.

Correspondence to: I Jane Cox, PhD, Institute of Hepatology, London, Foundation for Liver Research, 69-75 Chenies Mews, London WC1E 6HX, United Kingdom. j.cox@researchinliver.org.uk

Telephone: +44-207-2559830 Fax: +44-207-3800405

Received: December 1, 2015
Peer-review started: December 4, 2015
First decision: January 28, 2016
Revised: February 19, 2016
Accepted: March 1, 2016
Article in press: March 2, 2016
Published online: April 28, 2016
Processing time: 138 Days and 11 Hours

Core Tip

Core tip: Previous urinary metabolic profiling studies using nuclear magnetic resonance (NMR) spectroscopy of hepatocellular carcinoma (HCC) from Egypt and West Africa suggested the reproducibility of an identifying urinary metabolic profile in HCC. Here, a Bangladeshi HCC cohort was studied to identify similar changes. Urine samples from 142 subjects with hepatitis B HCC, cirrhosis, chronic hepatitis B, or no history of liver disease were analyzed using NMR. Urinary NMR from HCC differed across a range of metabolites, including reduced hippurate and creatinine and increased carnitine levels, consistent with the diverse effects of liver cancer on metabolic pathways and the interrelationship with the gut microbiome. Previous findings were corroborated, suggesting that a panel of metabolic markers could form the basis of a cost-effective HCC dipstick screening test.