Observational Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2016; 22(14): 3852-3859
Published online Apr 14, 2016. doi: 10.3748/wjg.v22.i14.3852
Integrin αvβ6 and matrix metalloproteinase 9 correlate with survival in gastric cancer
Pei-Long Lian, Zhao Liu, Guang-Yun Yang, Rui Zhao, Zhao-Yang Zhang, Yue-Guang Chen, Zhuo-Nan Zhuang, Ke-Sen Xu
Pei-Long Lian, Rui Zhao, Zhao-Yang Zhang, Yue-Guang Chen, Ke-Sen Xu, Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China
Zhao Liu, Department of Hepatobiliary and Pancreatic Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong Province, China
Guang-Yun Yang, Department of Hepatobiliary Surgery, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
Zhuo-Nan Zhuang, Department of General Surgery, Beijing Tsinghua Changgung Hospital Medical Center, Tsinghua University, Beijing 102218, China
Author contributions: Lian PL designed the research, drafted and revised the paper; Liu Z, Yang GY, Zhao R performed the research; Zhang ZY, Chen YG, Zhuang ZN searched the literature and analyzed the data; Xu KS revised the paper, approved the final version.
Supported by China Postdoctoral Science Foundation funded Project, No. 20080441310 and 201003781; and the Natural Science Foundation of China, No. 81302123.
Institutional review board statement: The study was reviewed and approved by QiLu Hospital Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We declare that there are no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ke-Sen Xu, PhD, Professor, Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan 250012, Shandong Province, China. xukesen0519@163.com
Telephone: +86-531-82169230 Fax: +86-531-82169243
Received: December 6, 2015
Peer-review started: December 7, 2015
First decision: December 31, 2015
Revised: January 11, 2016
Accepted: February 20, 2016
Article in press: February 22, 2016
Published online: April 14, 2016
Processing time: 113 Days and 18.4 Hours
Core Tip

Core tip: Both integrin αvβ6 and matrix metalloproteinase 9 (MMP-9) play an important role in the development and progression of cancer. However, the combined effect of the two proteins in gastric cancer is not yet clear. We would like to draw attention to this aspect. In the present study, we demonstrated that the expression of αvβ6 and MMP-9 are closely correlated, and the combinational pattern of αvβ6 and MMP-9 can serve as a more effective prognostic index for gastric cancer patients.