Engin A, Gonul II, Engin AB, Karamercan A, Sepici Dincel A, Dursun A. Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma. World J Gastroenterol 2016; 22(13): 3592-3601 [PMID: 27053851 DOI: 10.3748/wjg.v22.i13.3592]
Corresponding Author of This Article
Dr. Ayse Basak Engin, Associate Professor, Department of Toxicology, Faculty of Pharmacy, Gazi University, TR 06330 Hipodrom, Ankara, Turkey. abengin@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Engin A, Gonul II, Engin AB, Karamercan A, Sepici Dincel A, Dursun A. Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma. World J Gastroenterol 2016; 22(13): 3592-3601 [PMID: 27053851 DOI: 10.3748/wjg.v22.i13.3592]
World J Gastroenterol. Apr 7, 2016; 22(13): 3592-3601 Published online Apr 7, 2016. doi: 10.3748/wjg.v22.i13.3592
Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma
Atilla Engin, Ipek Isik Gonul, Ayse Basak Engin, Ahmet Karamercan, Aylin Sepici Dincel, Ayse Dursun
Atilla Engin, Ahmet Karamercan, Department of General Surgery, Faculty of Medicine, Gazi University, TR 06500 Beşevler, Ankara, Turkey
Ipek Isik Gonul, Ayse Dursun, Department of Pathology, Faculty of Medicine, Gazi University, TR 06500 Beşevler, Ankara, Turkey
Ayse Basak Engin, Department of Toxicology, Faculty of Pharmacy, Gazi University, TR 06330 Hipodrom, Ankara, Turkey
Aylin Sepici Dincel, Department of Biochemistry, Faculty of Medicine, Gazi University, TR 06500 Beşevler, Ankara, Turkey
Author contributions: Engin A designed and co-ordinated the study, selected the patients, did surgical interventions and wrote the manuscript; Gonul II and Dursun A did the immunohistochemical staining and analysis; Karamercan A involved in surgical interventions; Engin AB and Sepici Dincel A performed the experiments; and Engin AB involved in editing the manuscript.
Supported by Gazi University, Scientific Research Projects Division, No. 01/2007-62.
Institutional review board statement: The study was approved by Gazi University, Local Ethics Committee.
Informed consent statement: All participants’ rights were protected and informed consents were obtained according to the Helsinki Declaration.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: Participants gave informed consent for data sharing.
Correspondence to: Dr. Ayse Basak Engin, Associate Professor, Department of Toxicology, Faculty of Pharmacy, Gazi University, TR 06330 Hipodrom, Ankara, Turkey. abengin@gmail.com
Telephone: +90-312-2023084 Fax: +90-312-2222326
Received: September 11, 2015 Peer-review started: September 14, 2015 First decision: January 13, 2016 Revised: January 31, 2016 Accepted: March 2, 2016 Article in press: March 2, 2016 Published online: April 7, 2016 Processing time: 198 Days and 23.2 Hours
Core Tip
Core tip: Colorectal cancer (CRC) is one of the major public health problems in the world. Clinicopathological findings of patients who died of recurrent CRC after resection revealed that approximately 14% of patients with lymph node negative CRC die because of the presence of unrecognizable tumor cells that are categorized as micrometastases. Tryptophan degrading enzyme, indoleamine-2,3-dioxygenase expression by tumor cells has been shown to be correlated with a poor clinical prognosis of colon cancer. Our data indicated that high total indoleamine-2,3-dioxygenase immunostaining score is a strong predictor for immune tolerance, lymphatic invasion and subsequent lymph node metastasis. Therefore, indoleamine-2,3-dioxygenase immunostaining might be recommended for histopathological evaluation of CRC cases.
